diff --git a/src/strands/agent/agent.py b/src/strands/agent/agent.py
index e199608a2..7350ab7ed 100644
--- a/src/strands/agent/agent.py
+++ b/src/strands/agent/agent.py
@@ -577,27 +577,30 @@ def cleanup(self) -> None:
         self.tool_registry.cleanup()
 
     def add_hook(
-        self, callback: HookCallback[TEvent], event_type: type[TEvent] | None = None, **kwargs: dict[str, Any]
+        self, callback: HookCallback[TEvent], event_type: type[TEvent] | list[type[TEvent]] | None = None
     ) -> None:
         """Register a callback function for a specific event type.
 
-        This method supports two call patterns:
+        This method supports multiple call patterns:
         1. ``add_hook(callback)`` - Event type inferred from callback's type hint
         2. ``add_hook(callback, event_type)`` - Event type specified explicitly
+        3. ``add_hook(callback, [TypeA, TypeB])`` - Register for multiple event types
+
+        When the callback's type hint is a union type (``A | B`` or ``Union[A, B]``),
+        the callback is automatically registered for each event type in the union.
 
         Callbacks can be either synchronous or asynchronous functions.
 
         Args:
             callback: The callback function to invoke when events of this type occur.
-            event_type: The class type of events this callback should handle.
-                If not provided, the event type will be inferred from the callback's
-                first parameter type hint.
-            **kwargs: Additional arguments (ignored).
-
+            event_type: The class type(s) of events this callback should handle.
+                Can be a single type, a list of types, or None to infer from
+                the callback's first parameter type hint. If a list is provided,
+                the callback is registered for each type in the list.
 
         Raises:
             ValueError: If event_type is not provided and cannot be inferred from
-                the callback's type hints.
+                the callback's type hints, or if the event_type list is empty.
 
         Example:
             ```python
@@ -611,6 +614,16 @@ def log_model_call(event: BeforeModelCallEvent) -> None:
 
             # With explicit event type
             agent.add_hook(log_model_call, BeforeModelCallEvent)
+
+            # With union type hint (registers for all types)
+            def log_event(event: BeforeModelCallEvent | AfterModelCallEvent) -> None:
+                print(f"Event: {type(event).__name__}")
+            agent.add_hook(log_event)
+
+            # With list of event types
+            def multi_handler(event) -> None:
+                print(f"Event: {type(event).__name__}")
+            agent.add_hook(multi_handler, [BeforeModelCallEvent, AfterModelCallEvent])
             ```
         Docs:
             https://strandsagents.com/latest/documentation/docs/user-guide/concepts/agents/hooks/
diff --git a/src/strands/hooks/registry.py b/src/strands/hooks/registry.py
index 2f465a751..886ea5644 100644
--- a/src/strands/hooks/registry.py
+++ b/src/strands/hooks/registry.py
@@ -9,6 +9,7 @@
 
 import inspect
 import logging
+import types
 from collections.abc import Awaitable, Generator
 from dataclasses import dataclass
 from typing import (
@@ -17,6 +18,10 @@
     Generic,
     Protocol,
     TypeVar,
+    Union,
+    cast,
+    get_args,
+    get_origin,
     get_type_hints,
     runtime_checkable,
 )
@@ -167,22 +172,27 @@ def __init__(self) -> None:
 
     def add_callback(
         self,
-        event_type: type[TEvent] | None,
+        event_type: type[TEvent] | list[type[TEvent]] | None,
         callback: HookCallback[TEvent],
     ) -> None:
         """Register a callback function for a specific event type.
 
         If ``event_type`` is None, then this will check the callback handler type hint
-        for the lifecycle event type.
+        for the lifecycle event type. Union types (``A | B`` or ``Union[A, B]``) in
+        type hints will register the callback for each event type in the union.
+
+        If ``event_type`` is a list, the callback will be registered for each event
+        type in the list (duplicates are ignored).
 
         Args:
-            event_type: The class type of events this callback should handle.
+            event_type: The lifecycle event type(s) this callback should handle.
+                Can be a single type, a list of types, or None to infer from type hints.
             callback: The callback function to invoke when events of this type occur.
 
         Raises:
             ValueError: If event_type is not provided and cannot be inferred from
                 the callback's type hints, or if AgentInitializedEvent is registered
-                with an async callback.
+                with an async callback, or if the event_type list is empty.
 
         Example:
             ```python
@@ -194,35 +204,77 @@ def my_handler(event: StartRequestEvent):
 
             # With event type inferred from type hint
             registry.add_callback(None, my_handler)
+
+            # With union type hint (registers for both types)
+            def union_handler(event: BeforeModelCallEvent | AfterModelCallEvent):
+                print(f"Event: {type(event).__name__}")
+            registry.add_callback(None, union_handler)
+
+            # With list of event types
+            def multi_handler(event):
+                print(f"Event: {type(event).__name__}")
+            registry.add_callback([BeforeModelCallEvent, AfterModelCallEvent], multi_handler)
             ```
         """
-        resolved_event_type: type[TEvent]
-
-        # Support both add_callback(None, callback) and add_callback(event_type, callback)
-        if event_type is None:
-            # callback provided but event_type is None - infer it
-            resolved_event_type = self._infer_event_type(callback)
+        resolved_event_types: list[type[TEvent]]
+
+        # Handle list of event types
+        if isinstance(event_type, list):
+            if not event_type:
+                raise ValueError("event_type list cannot be empty")
+            resolved_event_types = self._validate_event_type_list(event_type)
+        elif event_type is None:
+            # Infer event type(s) from callback type hints
+            resolved_event_types = self._infer_event_types(callback)
         else:
-            resolved_event_type = event_type
+            # Single event type provided explicitly
+            resolved_event_types = [event_type]
 
-        # Related issue: https://github.com/strands-agents/sdk-python/issues/330
-        if resolved_event_type.__name__ == "AgentInitializedEvent" and inspect.iscoroutinefunction(callback):
-            raise ValueError("AgentInitializedEvent can only be registered with a synchronous callback")
+        # Deduplicate event types while preserving order
+        unique_event_types: set[type[TEvent]] = set(resolved_event_types)
 
-        callbacks = self._registered_callbacks.setdefault(resolved_event_type, [])
-        callbacks.append(callback)
+        # Register callback for each event type
+        for resolved_event_type in unique_event_types:
+            # Related issue: https://github.com/strands-agents/sdk-python/issues/330
+            if resolved_event_type.__name__ == "AgentInitializedEvent" and inspect.iscoroutinefunction(callback):
+                raise ValueError("AgentInitializedEvent can only be registered with a synchronous callback")
 
-    def _infer_event_type(self, callback: HookCallback[TEvent]) -> type[TEvent]:
-        """Infer the event type from a callback's type hints.
+            callbacks = self._registered_callbacks.setdefault(resolved_event_type, [])
+            callbacks.append(callback)
+
+    def _validate_event_type_list(self, event_types: list[type[TEvent]]) -> list[type[TEvent]]:
+        """Validate that all types in a list are valid BaseHookEvent subclasses.
+
+        Args:
+            event_types: List of event types to validate.
+
+        Returns:
+            The validated list of event types.
+
+        Raises:
+            ValueError: If any type is not a valid BaseHookEvent subclass.
+        """
+        validated: list[type[TEvent]] = []
+        for et in event_types:
+            if not (isinstance(et, type) and issubclass(et, BaseHookEvent)):
+                raise ValueError(f"Invalid event type: {et} | must be a subclass of BaseHookEvent")
+            validated.append(et)
+        return validated
+
+    def _infer_event_types(self, callback: HookCallback[TEvent]) -> list[type[TEvent]]:
+        """Infer the event type(s) from a callback's type hints.
+
+        Supports both single types and union types (A | B or Union[A, B]).
 
         Args:
             callback: The callback function to inspect.
 
         Returns:
-            The event type inferred from the callback's first parameter type hint.
+            A list of event types inferred from the callback's first parameter type hint.
 
         Raises:
-            ValueError: If the event type cannot be inferred from the callback's type hints.
+            ValueError: If the event type cannot be inferred from the callback's type hints,
+                or if a union contains None or non-BaseHookEvent types.
         """
         try:
             hints = get_type_hints(callback)
@@ -250,9 +302,21 @@ def _infer_event_type(self, callback: HookCallback[TEvent]) -> type[TEvent]:
                 "cannot infer event type, please provide event_type explicitly"
             )
 
+        # Check if it's a Union type (Union[A, B] or A | B)
+        origin = get_origin(type_hint)
+        if origin is Union or origin is types.UnionType:
+            event_types: list[type[TEvent]] = []
+            for arg in get_args(type_hint):
+                if arg is type(None):
+                    raise ValueError("None is not a valid event type in union")
+                if not (isinstance(arg, type) and issubclass(arg, BaseHookEvent)):
+                    raise ValueError(f"Invalid type in union: {arg} | must be a subclass of BaseHookEvent")
+                event_types.append(cast(type[TEvent], arg))
+            return event_types
+
         # Handle single type
         if isinstance(type_hint, type) and issubclass(type_hint, BaseHookEvent):
-            return type_hint  # type: ignore[return-value]
+            return [cast(type[TEvent], type_hint)]
 
         raise ValueError(
             f"parameter=<{first_param.name}>, type=<{type_hint}> | type hint must be a subclass of BaseHookEvent"
diff --git a/tests/strands/hooks/test_registry.py b/tests/strands/hooks/test_registry.py
index 5331bfa43..79829b92b 100644
--- a/tests/strands/hooks/test_registry.py
+++ b/tests/strands/hooks/test_registry.py
@@ -1,8 +1,16 @@
 import unittest.mock
+from typing import Union
 
 import pytest
 
-from strands.hooks import AgentInitializedEvent, BeforeInvocationEvent, BeforeToolCallEvent, HookRegistry
+from strands.hooks import (
+    AfterModelCallEvent,
+    AgentInitializedEvent,
+    BeforeInvocationEvent,
+    BeforeModelCallEvent,
+    BeforeToolCallEvent,
+    HookRegistry,
+)
 from strands.interrupt import Interrupt, _InterruptState
 
 
@@ -155,3 +163,148 @@ def callback(event: BeforeInvocationEvent) -> None:
 
     assert BeforeInvocationEvent in registry._registered_callbacks
     assert callback in registry._registered_callbacks[BeforeInvocationEvent]
+
+# ========== Tests for union type support ==========
+
+
+def test_hook_registry_add_callback_infers_union_types_pipe_syntax(registry):
+    """Test that add_callback registers callback for each type in A | B union."""
+
+    def union_callback(event: BeforeModelCallEvent | AfterModelCallEvent) -> None:
+        pass
+
+    registry.add_callback(None, union_callback)
+
+    # Callback should be registered for both event types
+    assert BeforeModelCallEvent in registry._registered_callbacks
+    assert AfterModelCallEvent in registry._registered_callbacks
+    assert union_callback in registry._registered_callbacks[BeforeModelCallEvent]
+    assert union_callback in registry._registered_callbacks[AfterModelCallEvent]
+
+
+def test_hook_registry_add_callback_infers_union_types_union_syntax(registry):
+    """Test that add_callback registers callback for each type in Union[A, B]."""
+
+    def union_callback(event: Union[BeforeModelCallEvent, AfterModelCallEvent]) -> None:  # noqa: UP007
+        pass
+
+    registry.add_callback(None, union_callback)
+
+    # Callback should be registered for both event types
+    assert BeforeModelCallEvent in registry._registered_callbacks
+    assert AfterModelCallEvent in registry._registered_callbacks
+    assert union_callback in registry._registered_callbacks[BeforeModelCallEvent]
+    assert union_callback in registry._registered_callbacks[AfterModelCallEvent]
+
+
+def test_hook_registry_add_callback_union_with_none_raises_error(registry):
+    """Test that add_callback raises error when union contains None."""
+
+    def callback_with_none(event: BeforeModelCallEvent | None) -> None:
+        pass
+
+    with pytest.raises(ValueError, match="None is not a valid event type"):
+        registry.add_callback(None, callback_with_none)
+
+
+def test_hook_registry_add_callback_union_with_invalid_type_raises_error(registry):
+    """Test that add_callback raises error when union contains non-BaseHookEvent type."""
+
+    def callback_with_invalid_type(event: BeforeModelCallEvent | str) -> None:
+        pass
+
+    with pytest.raises(ValueError, match="Invalid type in union"):
+        registry.add_callback(None, callback_with_invalid_type)
+
+
+def test_hook_registry_add_callback_union_multiple_types(registry):
+    """Test that add_callback handles union with more than two types."""
+
+    def multi_union_callback(event: BeforeModelCallEvent | AfterModelCallEvent | BeforeInvocationEvent) -> None:
+        pass
+
+    registry.add_callback(None, multi_union_callback)
+
+    # Callback should be registered for all three event types
+    assert BeforeModelCallEvent in registry._registered_callbacks
+    assert AfterModelCallEvent in registry._registered_callbacks
+    assert BeforeInvocationEvent in registry._registered_callbacks
+    assert multi_union_callback in registry._registered_callbacks[BeforeModelCallEvent]
+    assert multi_union_callback in registry._registered_callbacks[AfterModelCallEvent]
+    assert multi_union_callback in registry._registered_callbacks[BeforeInvocationEvent]
+
+
+# ========== Tests for list of types support ==========
+
+
+def test_hook_registry_add_callback_with_list_of_types(registry):
+    """Test that add_callback registers callback for each type in a list."""
+
+    def my_callback(event) -> None:
+        pass
+
+    registry.add_callback([BeforeModelCallEvent, AfterModelCallEvent], my_callback)
+
+    # Callback should be registered for both event types
+    assert BeforeModelCallEvent in registry._registered_callbacks
+    assert AfterModelCallEvent in registry._registered_callbacks
+    assert my_callback in registry._registered_callbacks[BeforeModelCallEvent]
+    assert my_callback in registry._registered_callbacks[AfterModelCallEvent]
+
+
+def test_hook_registry_add_callback_with_list_deduplicates(registry):
+    """Test that add_callback deduplicates event types in a list."""
+
+    def my_callback(event) -> None:
+        pass
+
+    # Same type appears multiple times
+    registry.add_callback([BeforeModelCallEvent, BeforeModelCallEvent, AfterModelCallEvent], my_callback)
+
+    # Callback should be registered only once per event type
+    assert len(registry._registered_callbacks[BeforeModelCallEvent]) == 1
+    assert len(registry._registered_callbacks[AfterModelCallEvent]) == 1
+
+
+def test_hook_registry_add_callback_with_list_validates_types(registry):
+    """Test that add_callback validates all types in a list are BaseHookEvent subclasses."""
+
+    def my_callback(event) -> None:
+        pass
+
+    with pytest.raises(ValueError, match="Invalid event type"):
+        registry.add_callback([BeforeModelCallEvent, str], my_callback)
+
+
+def test_hook_registry_add_callback_with_empty_list_raises_error(registry):
+    """Test that add_callback raises error when given an empty list."""
+
+    def my_callback(event) -> None:
+        pass
+
+    with pytest.raises(ValueError, match="event_type list cannot be empty"):
+        registry.add_callback([], my_callback)
+
+
+@pytest.mark.asyncio
+async def test_hook_registry_union_callback_invoked_for_each_type(registry, agent):
+    """Test that a union-registered callback is invoked correctly for each event type."""
+    call_count = {"before": 0, "after": 0}
+
+    def union_callback(event: BeforeModelCallEvent | AfterModelCallEvent) -> None:
+        if isinstance(event, BeforeModelCallEvent):
+            call_count["before"] += 1
+        elif isinstance(event, AfterModelCallEvent):
+            call_count["after"] += 1
+
+    registry.add_callback(None, union_callback)
+
+    # Invoke BeforeModelCallEvent
+    before_event = BeforeModelCallEvent(agent=agent)
+    await registry.invoke_callbacks_async(before_event)
+    assert call_count["before"] == 1
+
+    # Invoke AfterModelCallEvent
+    after_event = AfterModelCallEvent(agent=agent)
+    await registry.invoke_callbacks_async(after_event)
+    assert call_count["after"] == 1