diff --git a/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_th2.py b/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_th2.py
index 7691247a94cc0..547a48a8ff849 100644
--- a/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_th2.py
+++ b/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_th2.py
@@ -83,7 +83,9 @@ def _TH2Poly_AddBin(self, *args, **kwargs):
     # "TH2PolyBin", Does not derive from TH2
     "TProfile2D",
     # "TProfile2PolyBin", Derives from TH2PolyBin which does not derive from TH2
-    "TProfile2Poly",
+    # "TProfile2Poly", # Like TH2Poly (its base), its bins are polygons addressed by a
+    #                  # single global bin number, not an (i, j) grid, so it does not fit
+    #                  # the rectangular UHI plotting/indexing model.
 ]
 
 for klass in _th2_derived_classes_to_pythonize:
diff --git a/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_uhi/__init__.py b/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_uhi/__init__.py
index 26dd4fe1f67f1..901d234f3b647 100644
--- a/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_uhi/__init__.py
+++ b/bindings/pyroot/pythonizations/python/ROOT/_pythonization/_uhi/__init__.py
@@ -51,7 +51,6 @@ def _add_indexing_features(klass: Any) -> None:
     "TH3C": _values_by_copy,
     "TProfile": _values_by_copy,
     "TProfile2D": _values_by_copy,
-    "TProfile2Poly": _values_by_copy,
     "TProfile3D": _values_by_copy,
 }
 
diff --git a/bindings/pyroot/pythonizations/test/uhi_indexing.py b/bindings/pyroot/pythonizations/test/uhi_indexing.py
index 2618e925df935..1ff3ccf867b84 100644
--- a/bindings/pyroot/pythonizations/test/uhi_indexing.py
+++ b/bindings/pyroot/pythonizations/test/uhi_indexing.py
@@ -16,7 +16,7 @@ def _special_setting(hist):
     # For these classes, SetBinContent works differently than for other classes,
     # as in it does not set the bin content to the specified value, but does some other calculations
     # for that, these classes will be tested differently
-    return isinstance(hist, (ROOT.TProfile, ROOT.TProfile2D, ROOT.TProfile2Poly, ROOT.TProfile3D))
+    return isinstance(hist, (ROOT.TProfile, ROOT.TProfile2D, ROOT.TProfile3D))
 
 
 def _get_index_for_dimension(hist, index):
diff --git a/bindings/pyroot/pythonizations/test/uhi_plotting.py b/bindings/pyroot/pythonizations/test/uhi_plotting.py
index ca215b3a27980..0842838793ec9 100644
--- a/bindings/pyroot/pythonizations/test/uhi_plotting.py
+++ b/bindings/pyroot/pythonizations/test/uhi_plotting.py
@@ -12,9 +12,7 @@
 
 def _not_writable(hist):
     # For these classes, the values() method always returns a copy so writable=True is not supported.
-    return isinstance(
-        hist, (ROOT.TH1C, ROOT.TH2C, ROOT.TH3C, ROOT.TProfile, ROOT.TProfile2D, ROOT.TProfile2Poly, ROOT.TProfile3D)
-    )
+    return isinstance(hist, (ROOT.TH1C, ROOT.TH2C, ROOT.TH3C, ROOT.TProfile, ROOT.TProfile2D, ROOT.TProfile3D))
 
 
 class TestTH1Plotting: