diff --git a/changelog.d/1571.change.md b/changelog.d/1571.change.md
new file mode 100644
index 000000000..ff5bafd02
--- /dev/null
+++ b/changelog.d/1571.change.md
@@ -0,0 +1 @@
+Added new validator ``ne(val)`` (!= val).
diff --git a/docs/api.rst b/docs/api.rst
index ee84d9de1..c8ab29a41 100644
--- a/docs/api.rst
+++ b/docs/api.rst
@@ -396,6 +396,22 @@ All objects from ``attrs.validators`` are also available from ``attr.validators`
          ...
       ValueError: ("'x' must be > 42: 42")
 
+.. autofunction:: attrs.validators.ne
+
+   For example:
+
+   .. doctest::
+
+      >>> @define
+      ... class C:
+      ...     x = field(validator=attrs.validators.ne(42))
+      >>> C(43)
+      C(x=43)
+      >>> C(42)
+      Traceback (most recent call last):
+         ...
+      ValueError: ("'x' must be != 42: 42")
+
 .. autofunction:: attrs.validators.max_len
 
    For example:
diff --git a/src/attr/validators.py b/src/attr/validators.py
index 0b1a29443..d6fb2a47d 100644
--- a/src/attr/validators.py
+++ b/src/attr/validators.py
@@ -32,6 +32,7 @@
     "matches_re",
     "max_len",
     "min_len",
+    "ne",
     "not_",
     "optional",
     "or_",
@@ -156,10 +157,10 @@ def matches_re(regex, flags=0, func=None):
 
     Args:
         regex (str, re.Pattern):
-            A regex string or precompiled pattern to match against
+            A regex string or precompiled pattern to match against.
 
         flags (int):
-            Flags that will be passed to the underlying re function (default 0)
+            Flags that will be passed to the underlying re function (default 0).
 
         func (typing.Callable):
             Which underlying `re` function to call. Valid options are
@@ -368,8 +369,8 @@ def deep_iterable(member_validator, iterable_validator=None):
         iterable_validator:
             Validator(s) to apply to iterable itself (optional).
 
-    Raises
-        TypeError: if any sub-validators fail
+    Raises:
+        TypeError: if any sub-validators fail.
 
     .. versionadded:: 19.1.0
 
@@ -513,7 +514,7 @@ def ge(val):
     The validator uses `operator.ge` to compare the values.
 
     Args:
-        val: Inclusive lower bound for values
+        val: Inclusive lower bound for values.
 
     .. versionadded:: 21.3.0
     """
@@ -528,13 +529,28 @@ def gt(val):
     The validator uses `operator.gt` to compare the values.
 
     Args:
-       val: Exclusive lower bound for values
+       val: Exclusive lower bound for values.
 
     .. versionadded:: 21.3.0
     """
     return _NumberValidator(val, ">", operator.gt)
 
 
+def ne(val):
+    """
+    A validator that raises `ValueError` if the initializer is called with a
+    number equal to *val*.
+
+    The validator uses `operator.ne` to compare the values.
+
+    Args:
+       val: The value that is not allowed.
+
+    .. versionadded:: 26.2.0
+    """
+    return _NumberValidator(val, "!=", operator.ne)
+
+
 @attrs(repr=False, frozen=True, slots=True)
 class _MaxLengthValidator:
     max_length = attrib()
@@ -557,7 +573,7 @@ def max_len(length):
     with a string or iterable that is longer than *length*.
 
     Args:
-        length (int): Maximum length of the string or iterable
+        length (int): Maximum length of the string or iterable.
 
     .. versionadded:: 21.3.0
     """
@@ -586,7 +602,7 @@ def min_len(length):
     with a string or iterable that is shorter than *length*.
 
     Args:
-        length (int): Minimum length of the string or iterable
+        length (int): Minimum length of the string or iterable.
 
     .. versionadded:: 22.1.0
     """
diff --git a/src/attr/validators.pyi b/src/attr/validators.pyi
index 18fb112c8..384159216 100644
--- a/src/attr/validators.pyi
+++ b/src/attr/validators.pyi
@@ -85,6 +85,7 @@ def lt(val: _T) -> _ValidatorType[_T]: ...
 def le(val: _T) -> _ValidatorType[_T]: ...
 def ge(val: _T) -> _ValidatorType[_T]: ...
 def gt(val: _T) -> _ValidatorType[_T]: ...
+def ne(val: _T) -> _ValidatorType[_T]: ...
 def max_len(length: int) -> _ValidatorType[_T]: ...
 def min_len(length: int) -> _ValidatorType[_T]: ...
 def not_(
diff --git a/tests/test_validators.py b/tests/test_validators.py
index 8caa64272..cbd087dd1 100644
--- a/tests/test_validators.py
+++ b/tests/test_validators.py
@@ -28,6 +28,7 @@
     matches_re,
     max_len,
     min_len,
+    ne,
     not_,
     optional,
     or_,
@@ -875,9 +876,9 @@ def test_hashability():
         assert hash_func is not object.__hash__
 
 
-class TestLtLeGeGt:
+class TestLtLeGeGtNe:
     """
-    Tests for `Lt, Le, Ge, Gt`.
+    Tests for `Lt, Le, Ge, Gt, Ne`.
     """
 
     BOUND = 4
@@ -887,10 +888,11 @@ def test_in_all(self):
         validator is in ``__all__``.
         """
         assert all(
-            f.__name__ in validator_module.__all__ for f in [lt, le, ge, gt]
+            f.__name__ in validator_module.__all__
+            for f in [lt, le, ge, gt, ne]
         )
 
-    @pytest.mark.parametrize("v", [lt, le, ge, gt])
+    @pytest.mark.parametrize("v", [lt, le, ge, gt, ne])
     def test_retrieve_bound(self, v):
         """
         The configured bound for the comparison can be extracted from the
@@ -906,12 +908,14 @@ class Tester:
     @pytest.mark.parametrize(
         ("v", "value"),
         [
+            (ne, 3),
             (lt, 3),
             (le, 3),
             (le, 4),
             (ge, 4),
             (ge, 5),
             (gt, 5),
+            (ne, 5),
         ],
     )
     def test_check_valid(self, v, value):
@@ -930,6 +934,7 @@ class Tester:
             (le, 5),
             (ge, 3),
             (gt, 4),
+            (ne, 4),
         ],
     )
     def test_check_invalid(self, v, value):
@@ -942,7 +947,7 @@ class Tester:
         with pytest.raises(ValueError):
             Tester(value)
 
-    @pytest.mark.parametrize("v", [lt, le, ge, gt])
+    @pytest.mark.parametrize("v", [lt, le, ge, gt, ne])
     def test_repr(self, v):
         """
         __repr__ is meaningful.