diff --git a/.changeset/tooltip-close-when-popup-opens.md b/.changeset/tooltip-close-when-popup-opens.md
new file mode 100644
index 00000000000..96c5cf02dd4
--- /dev/null
+++ b/.changeset/tooltip-close-when-popup-opens.md
@@ -0,0 +1,5 @@
+---
+'@primer/react': patch
+---
+
+Tooltip: Close an open tooltip when its trigger opens a popup, so the popup can handle the Escape key
diff --git a/package-lock.json b/package-lock.json
index 5b659be6320..e954690b928 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -63,7 +63,7 @@
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@@ -84,7 +84,7 @@
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+        "@primer/react": "38.39.0",
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@@ -98,7 +98,7 @@
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+        "@primer/react": "38.39.0",
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+        "@primer/react": "38.39.0",
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@@ -8385,23 +8385,23 @@
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+      "resolved": "https://registry.npmjs.org/@storybook/addon-docs/-/addon-docs-10.6.0.tgz",
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@@ -8436,9 +8436,9 @@
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+        "@storybook/addon-vitest": "^10.6.0",
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@@ -8487,13 +8489,12 @@
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+      "version": "10.6.0",
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@@ -8501,45 +8502,10 @@
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         "@vitest/spy": "3.2.4",
         "@webcontainer/env": "^1.1.1",
@@ -27908,9 +27836,9 @@
       }
     },
     "node_modules/tmcp": {
-      "version": "1.19.4",
-      "resolved": "https://registry.npmjs.org/tmcp/-/tmcp-1.19.4.tgz",
-      "integrity": "sha512-fMoUJ3Gef9iA0yKZNeW2SQCCKTluCwghUyOz/qxPS8XxrQk6Jlw4lgql3S+s6L//FteLeSJ7erKxMWl727mZoQ==",
+      "version": "1.20.0",
+      "resolved": "https://registry.npmjs.org/tmcp/-/tmcp-1.20.0.tgz",
+      "integrity": "sha512-dcDximKQBGqLP/aEAVA26HcWRHhKipstg1w0fbDDJ0HcFZ6lolLU1YYmStYEn/73f534i7WrDNcjRfRYdV9CoA==",
       "dev": true,
       "license": "MIT",
       "dependencies": {
@@ -29167,9 +29095,9 @@
       "license": "MIT"
     },
     "node_modules/valibot": {
-      "version": "1.2.0",
-      "resolved": "https://registry.npmjs.org/valibot/-/valibot-1.2.0.tgz",
-      "integrity": "sha512-mm1rxUsmOxzrwnX5arGS+U4T25RdvpPjPN4yR0u9pUBov9+zGVtO84tif1eY4r6zWxVxu3KzIyknJy3rxfRZZg==",
+      "version": "1.4.2",
+      "resolved": "https://registry.npmjs.org/valibot/-/valibot-1.4.2.tgz",
+      "integrity": "sha512-gjdCvJ6d3RyHAneqxMYMW9QMCwYMb3jpOO0IyHZV1bnRHFBHrX3VkIILt5XYR0WhwHiH7Mty8ovuPZ/O3gamrg==",
       "dev": true,
       "license": "MIT",
       "peerDependencies": {
@@ -29920,16 +29848,6 @@
         "node": ">=18"
       }
     },
-    "node_modules/vitest/node_modules/magic-string": {
-      "version": "1.2.3",
-      "resolved": "https://registry.npmjs.org/magic-string/-/magic-string-1.2.3.tgz",
-      "integrity": "sha512-Bpb0W2TbLKOZ7vJnOUnVRGq3WL2p+ISV29M6hYPL1AFCpyKZpdr5ytiXoTSSxRVhg8YW7f65+6gbG8WG6PCa/g==",
-      "dev": true,
-      "license": "MIT",
-      "dependencies": {
-        "@jridgewell/sourcemap-codec": "^1.5.5"
-      }
-    },
     "node_modules/vitest/node_modules/picomatch": {
       "version": "4.0.7",
       "resolved": "https://registry.npmjs.org/picomatch/-/picomatch-4.0.7.tgz",
@@ -30633,7 +30551,7 @@
     },
     "packages/react": {
       "name": "@primer/react",
-      "version": "38.38.0",
+      "version": "38.39.0",
       "license": "MIT",
       "dependencies": {
         "@github/mini-throttle": "^2.1.1",
@@ -30670,12 +30588,12 @@
         "@primer/doc-gen": "^0.0.1",
         "@primer/react-compiler-check": "^0.0.0",
         "@rolldown/plugin-babel": "^0.2.3",
-        "@storybook/addon-a11y": "10.5.10",
-        "@storybook/addon-docs": "10.5.10",
-        "@storybook/addon-links": "10.5.10",
-        "@storybook/addon-mcp": "^0.7.0",
+        "@storybook/addon-a11y": "10.6.0",
+        "@storybook/addon-docs": "10.6.0",
+        "@storybook/addon-links": "10.6.0",
+        "@storybook/addon-mcp": "^10.6.0",
         "@storybook/icons": "^2.1.0",
-        "@storybook/react-vite": "10.5.10",
+        "@storybook/react-vite": "^10.6.0",
         "@testing-library/dom": "^10.4.0",
         "@testing-library/jest-dom": "^6.4.5",
         "@testing-library/react": "^16.3.0",
@@ -30733,7 +30651,7 @@
         "rolldown-plugin-dts": "^0.26.0",
         "rolldown-plugin-import-css": "^0.0.0",
         "rolldown-plugin-preserve-directives": "^0.0.0",
-        "storybook": "10.5.10",
+        "storybook": "10.6.0",
         "terser": "5.36.0",
         "ts-toolbelt": "9.6.0",
         "tsx": "4.20.3",
@@ -31628,7 +31546,7 @@
         "@primer/primitives": "10.x || 11.x",
         "@primer/react": "^38.36.0",
         "@rolldown/plugin-babel": "^0.2.3",
-        "@storybook/react-vite": "10.5.10",
+        "@storybook/react-vite": "^10.6.0",
         "@types/babel__core": "^7.20.5",
         "@types/react": "18.3.11",
         "@types/react-dom": "18.3.1",
diff --git a/package.json b/package.json
index fe4e0369a09..c5555cf494f 100644
--- a/package.json
+++ b/package.json
@@ -92,7 +92,7 @@
     "prettier": "3.4.2",
     "rimraf": "5.0.5",
     "size-limit": "11.2.0",
-    "storybook": "10.5.10",
+    "storybook": "10.6.0",
     "stylelint": "17.4.0",
     "turbo": "^2.9.18",
     "typescript": "^6.0.3",
diff --git a/packages/react/package.json b/packages/react/package.json
index 8901a06fee2..257bcd174c3 100644
--- a/packages/react/package.json
+++ b/packages/react/package.json
@@ -107,12 +107,12 @@
     "@primer/doc-gen": "^0.0.1",
     "@primer/react-compiler-check": "^0.0.0",
     "@rolldown/plugin-babel": "^0.2.3",
-    "@storybook/addon-a11y": "10.5.10",
-    "@storybook/addon-docs": "10.5.10",
-    "@storybook/addon-links": "10.5.10",
-    "@storybook/addon-mcp": "^0.7.0",
+    "@storybook/addon-a11y": "10.6.0",
+    "@storybook/addon-docs": "10.6.0",
+    "@storybook/addon-links": "10.6.0",
+    "@storybook/addon-mcp": "^10.6.0",
     "@storybook/icons": "^2.1.0",
-    "@storybook/react-vite": "10.5.10",
+    "@storybook/react-vite": "10.6.0",
     "@testing-library/dom": "^10.4.0",
     "@testing-library/jest-dom": "^6.4.5",
     "@testing-library/react": "^16.3.0",
@@ -170,7 +170,7 @@
     "rolldown-plugin-dts": "^0.26.0",
     "rolldown-plugin-import-css": "^0.0.0",
     "rolldown-plugin-preserve-directives": "^0.0.0",
-    "storybook": "10.5.10",
+    "storybook": "10.6.0",
     "terser": "5.36.0",
     "ts-toolbelt": "9.6.0",
     "tsx": "4.20.3",
diff --git a/packages/react/src/Breadcrumbs/Breadcrumbs.tsx b/packages/react/src/Breadcrumbs/Breadcrumbs.tsx
index 00f3f266787..1cd5d681fe5 100644
--- a/packages/react/src/Breadcrumbs/Breadcrumbs.tsx
+++ b/packages/react/src/Breadcrumbs/Breadcrumbs.tsx
@@ -109,6 +109,7 @@ const BreadcrumbsMenuItem = React.forwardRef<HTMLDetailsElement, BreadcrumbsMenu
           ref={menuButtonRef}
           aria-label={ariaLabel || `${items.length} more breadcrumb items`}
           aria-expanded={isOpen ? 'true' : 'false'}
+          aria-haspopup="true"
           onClick={handleSummaryClick}
           variant="invisible"
           size="small"
diff --git a/packages/react/src/TooltipV2/Tooltip.tsx b/packages/react/src/TooltipV2/Tooltip.tsx
index 840ded8fc91..fb081a9af4c 100644
--- a/packages/react/src/TooltipV2/Tooltip.tsx
+++ b/packages/react/src/TooltipV2/Tooltip.tsx
@@ -274,6 +274,17 @@ export const Tooltip: ForwardRefExoticComponent<
       tooltip.setAttribute('popover', 'auto')
     }, [tooltipElRef, readTriggerRef, direction, type])
 
+    // If the tooltip gets disabled while it is open (e.g. because the trigger opened a popup),
+    // close it so it does not linger on top of the popup or swallow the Escape key press.
+    useEffect(() => {
+      // eslint-disable-next-line react-you-might-not-need-an-effect/no-event-handler
+      if (_privateDisableTooltip && isPopoverOpen) {
+        // eslint-disable-next-line react-you-might-not-need-an-effect/no-derived-state, react-you-might-not-need-an-effect/no-chain-state-updates
+        closeTooltip()
+      }
+      // eslint-disable-next-line react-hooks/exhaustive-deps
+    }, [_privateDisableTooltip, isPopoverOpen])
+
     useOnEscapePress(
       (event: KeyboardEvent) => {
         if (isPopoverOpen) {
diff --git a/packages/styled-react/package.json b/packages/styled-react/package.json
index 9ac46e96f64..e23fc30dee0 100644
--- a/packages/styled-react/package.json
+++ b/packages/styled-react/package.json
@@ -46,7 +46,7 @@
     "@primer/primitives": "10.x || 11.x",
     "@primer/react": "^38.36.0",
     "@rolldown/plugin-babel": "^0.2.3",
-    "@storybook/react-vite": "10.5.10",
+    "@storybook/react-vite": "10.6.0",
     "@types/babel__core": "^7.20.5",
     "@types/react": "18.3.11",
     "@types/react-dom": "18.3.1",