diff --git a/CHANGELOG.md b/CHANGELOG.md
index e991ae533a..a01a986bcc 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -25,6 +25,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#4006](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4006))
 - `opentelemetry-instrumentation-flask`: Add support for 3.1+ streaming responses
   ([#3938](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3938))
+- `opentelemetry-instrumentation`: Add support for wrapt 2
+  ([#4082](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4082))
 - `opentelemetry-instrumentation-aiohttp-server`: Support passing `TracerProvider` when instrumenting.
   ([#3819](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3819))
 - `opentelemetry-instrumentation-system-metrics`: Add support for the `OTEL_PYTHON_SYSTEM_METRICS_EXCLUDED_METRICS` environment variable
diff --git a/opentelemetry-instrumentation/pyproject.toml b/opentelemetry-instrumentation/pyproject.toml
index 0e5820e0d7..0773a736dd 100644
--- a/opentelemetry-instrumentation/pyproject.toml
+++ b/opentelemetry-instrumentation/pyproject.toml
@@ -27,7 +27,7 @@ classifiers = [
 dependencies = [
   "opentelemetry-api ~= 1.4",
   "opentelemetry-semantic-conventions == 0.61b0.dev",
-  "wrapt >= 1.0.0, < 2.0.0",
+  "wrapt >= 1.0.0",
   "packaging >= 18.0",
 ]
 
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py
index e38932e28d..9e3929f049 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py
@@ -20,7 +20,10 @@
 from re import escape, sub
 from typing import Any, Dict, Generator, Sequence
 
-from wrapt import ObjectProxy
+try:
+    from wrapt import BaseObjectProxy
+except ImportError:
+    from wrapt import ObjectProxy as BaseObjectProxy
 
 from opentelemetry import context, trace
 
@@ -108,7 +111,7 @@ def unwrap(obj: object, attr: str):
             ) from exc
 
     func = getattr(obj, attr, None)
-    if func and isinstance(func, ObjectProxy) and hasattr(func, "__wrapped__"):
+    if func and isinstance(func, BaseObjectProxy) and hasattr(func, "__wrapped__"):
         setattr(obj, attr, func.__wrapped__)
 
 
diff --git a/opentelemetry-instrumentation/tests/test_utils.py b/opentelemetry-instrumentation/tests/test_utils.py
index 5ddd45d692..8cd3a77e7f 100644
--- a/opentelemetry-instrumentation/tests/test_utils.py
+++ b/opentelemetry-instrumentation/tests/test_utils.py
@@ -15,7 +15,11 @@
 import unittest
 from http import HTTPStatus
 
-from wrapt import ObjectProxy, wrap_function_wrapper
+from wrapt import wrap_function_wrapper
+try:
+    from wrapt import BaseObjectProxy
+except ImportError:
+    from wrapt import ObjectProxy as BaseObjectProxy
 
 from opentelemetry.context import (
     _SUPPRESS_HTTP_INSTRUMENTATION_KEY,
@@ -263,23 +267,23 @@ def _wrap_method():
     def test_can_unwrap_object_attribute(self):
         self._wrap_method()
         instance = WrappedClass()
-        self.assertTrue(isinstance(instance.method, ObjectProxy))
+        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
 
         unwrap(WrappedClass, "method")
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
 
     def test_can_unwrap_object_attribute_as_string(self):
         self._wrap_method()
         instance = WrappedClass()
-        self.assertTrue(isinstance(instance.method, ObjectProxy))
+        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
 
         unwrap("tests.test_utils.WrappedClass", "method")
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
 
     def test_raises_import_error_if_path_not_well_formed(self):
         self._wrap_method()
         instance = WrappedClass()
-        self.assertTrue(isinstance(instance.method, ObjectProxy))
+        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
 
         with self.assertRaisesRegex(
             ImportError, "Cannot parse '' as dotted import path"
@@ -287,23 +291,23 @@ def test_raises_import_error_if_path_not_well_formed(self):
             unwrap("", "method")
 
         unwrap(WrappedClass, "method")
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
 
     def test_raises_import_error_if_cannot_find_module(self):
         self._wrap_method()
         instance = WrappedClass()
-        self.assertTrue(isinstance(instance.method, ObjectProxy))
+        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
 
         with self.assertRaisesRegex(ImportError, "No module named 'does'"):
             unwrap("does.not.exist.WrappedClass", "method")
 
         unwrap(WrappedClass, "method")
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
 
     def test_raises_import_error_if_cannot_find_object(self):
         self._wrap_method()
         instance = WrappedClass()
-        self.assertTrue(isinstance(instance.method, ObjectProxy))
+        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
 
         with self.assertRaisesRegex(
             ImportError, "Cannot import 'NotWrappedClass' from"
@@ -311,7 +315,7 @@ def test_raises_import_error_if_cannot_find_object(self):
             unwrap("tests.test_utils.NotWrappedClass", "method")
 
         unwrap(WrappedClass, "method")
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
 
     # pylint: disable=no-self-use
     def test_does_nothing_if_cannot_find_attribute(self):
@@ -320,6 +324,6 @@ def test_does_nothing_if_cannot_find_attribute(self):
 
     def test_does_nothing_if_attribute_is_not_from_wrapt(self):
         instance = WrappedClass()
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
         unwrap(WrappedClass, "method")
-        self.assertFalse(isinstance(instance.method, ObjectProxy))
+        self.assertFalse(isinstance(instance.method, BaseObjectProxy))