diff --git a/.github/workflows/python.yml b/.github/workflows/python.yml
index d9bc978d1..802f7c3d4 100644
--- a/.github/workflows/python.yml
+++ b/.github/workflows/python.yml
@@ -17,10 +17,8 @@ jobs:
       - name: Checkout repository
         uses: actions/checkout@v4
 
-      - name: Setup Python
-        uses: actions/setup-python@v4
-        with:
-          python-version: '3.10'
+      - name: Install uv
+        uses: astral-sh/setup-uv@v7
 
       - name: Generate Python bindings
         run: ./scripts/uniffi_bindgen_generate_python.sh
@@ -28,10 +26,6 @@ jobs:
       - name: Start bitcoind and electrs
         run: docker compose up -d
 
-      - name: Install testing prerequisites
-        run: |
-          pip3 install requests
-
       - name: Run Python unit tests
         env:
           BITCOIN_CLI_BIN: "docker exec ldk-node-bitcoin-1 bitcoin-cli"
@@ -40,4 +34,4 @@ jobs:
           ESPLORA_ENDPOINT: "http://127.0.0.1:3002"
         run: |
           cd $LDK_NODE_PYTHON_DIR
-          python3 -m unittest discover -s src/ldk_node
+          uv run --group dev python -m unittest discover -s src/ldk_node
diff --git a/bindings/python/hatch_build.py b/bindings/python/hatch_build.py
new file mode 100644
index 000000000..bd5f54d24
--- /dev/null
+++ b/bindings/python/hatch_build.py
@@ -0,0 +1,7 @@
+from hatchling.builders.hooks.plugin.interface import BuildHookInterface
+
+
+class CustomBuildHook(BuildHookInterface):
+    def initialize(self, version, build_data):
+        build_data["pure_python"] = False
+        build_data["infer_tag"] = True
diff --git a/bindings/python/pyproject.toml b/bindings/python/pyproject.toml
index 18ba319c4..b77801d45 100644
--- a/bindings/python/pyproject.toml
+++ b/bindings/python/pyproject.toml
@@ -1,3 +1,7 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
 [project]
 name = "ldk_node"
 version = "0.7.0"
@@ -5,8 +9,8 @@ authors = [
   { name="Elias Rohrer", email="dev@tnull.de" },
 ]
 description = "A ready-to-go Lightning node library built using LDK and BDK."
-readme = "README.md"
-requires-python = ">=3.6"
+readme = "../../README.md"
+requires-python = ">=3.8"
 classifiers = [
     "Topic :: Software Development :: Libraries",
     "Topic :: Security :: Cryptography",
@@ -19,3 +23,11 @@ classifiers = [
 "Homepage" = "https://lightningdevkit.org/"
 "Github" = "https://github.com/lightningdevkit/ldk-node"
 "Bug Tracker" = "https://github.com/lightningdevkit/ldk-node/issues"
+
+[dependency-groups]
+dev = ["requests"]
+
+[tool.hatch.build.targets.wheel]
+packages = ["src/ldk_node"]
+
+[tool.hatch.build.hooks.custom]
diff --git a/bindings/python/setup.cfg b/bindings/python/setup.cfg
deleted file mode 100644
index bd4e64216..000000000
--- a/bindings/python/setup.cfg
+++ /dev/null
@@ -1,13 +0,0 @@
-[options]
-packages = find:
-package_dir =
-    = src
-include_package_data = True
-
-[options.packages.find]
-where = src
-
-[options.package_data]
-ldk_node =
-    *.so
-    *.dylib
diff --git a/scripts/python_build_wheel.sh b/scripts/python_build_wheel.sh
new file mode 100755
index 000000000..4bae18479
--- /dev/null
+++ b/scripts/python_build_wheel.sh
@@ -0,0 +1,31 @@
+#!/bin/bash
+# Build a Python wheel for the current platform.
+#
+# This script compiles the Rust library, generates Python bindings via UniFFI,
+# and builds a platform-specific wheel using uv + hatchling.
+#
+# Run this on each target platform (Linux, macOS) to collect wheels, then use
+# scripts/python_publish_package.sh to publish them.
+
+set -e
+
+SCRIPT_DIR="$(cd "$(dirname "${BASH_SOURCE[0]}")" && pwd)"
+REPO_ROOT="$(cd "$SCRIPT_DIR/.." && pwd)"
+
+cd "$REPO_ROOT"
+
+# Generate bindings and compile the native library
+echo "Generating Python bindings..."
+./scripts/uniffi_bindgen_generate_python.sh
+
+# Build the wheel
+echo "Building wheel..."
+cd bindings/python
+uv build --wheel
+
+echo ""
+echo "Wheel built successfully:"
+ls -1 dist/*.whl
+echo ""
+echo "Collect wheels from all target platforms into dist/, then run:"
+echo "  ./scripts/python_publish_package.sh"
diff --git a/scripts/python_create_package.sh b/scripts/python_create_package.sh
deleted file mode 100755
index 0a993c9cb..000000000
--- a/scripts/python_create_package.sh
+++ /dev/null
@@ -1,3 +0,0 @@
-#!/bin/bash
-cd bindings/python || exit 1
-python3 -m build
diff --git a/scripts/python_publish_package.sh b/scripts/python_publish_package.sh
new file mode 100755
index 000000000..971a4edda
--- /dev/null
+++ b/scripts/python_publish_package.sh
@@ -0,0 +1,26 @@
+#!/bin/bash
+# Publish Python wheels to PyPI (or TestPyPI).
+#
+# Usage:
+#   ./scripts/python_publish_package.sh                    # publish to PyPI
+#   ./scripts/python_publish_package.sh --index testpypi   # publish to TestPyPI
+#
+# Before running, collect wheels from all target platforms into bindings/python/dist/.
+
+set -e
+
+SCRIPT_DIR="$(cd "$(dirname "${BASH_SOURCE[0]}")" && pwd)"
+REPO_ROOT="$(cd "$SCRIPT_DIR/.." && pwd)"
+DIST_DIR="$REPO_ROOT/bindings/python/dist"
+
+if [ ! -d "$DIST_DIR" ] || [ -z "$(ls -A "$DIST_DIR"/*.whl 2>/dev/null)" ]; then
+	echo "Error: No wheels found in $DIST_DIR"
+	echo "Run ./scripts/python_build_wheel.sh on each target platform first."
+	exit 1
+fi
+
+echo "Wheels to publish:"
+ls -1 "$DIST_DIR"/*.whl
+echo ""
+
+uv publish "$@" "$DIST_DIR"/*.whl