diff --git a/core/src/components/radio-group/radio-group.tsx b/core/src/components/radio-group/radio-group.tsx
index 37e0f0da0c9..4659d4e1d7e 100644
--- a/core/src/components/radio-group/radio-group.tsx
+++ b/core/src/components/radio-group/radio-group.tsx
@@ -1,6 +1,6 @@
 import type { ComponentInterface, EventEmitter } from '@stencil/core';
 import { Build, Component, Element, Event, Host, Listen, Method, Prop, State, Watch, h } from '@stencil/core';
-import { checkInvalidState } from '@utils/forms';
+import { checkInvalidState, isOptionSelected } from '@utils/forms';
 import { renderHiddenInput } from '@utils/helpers';
 
 import { getIonMode } from '../../global/ionic-global';
@@ -104,7 +104,7 @@ export class RadioGroup implements ComponentInterface {
 
     // Get the first radio that is not disabled and the checked one
     const first = radios.find((radio) => !radio.disabled);
-    const checked = radios.find((radio) => radio.value === value && !radio.disabled);
+    const checked = radios.find((radio) => isOptionSelected(value, radio.value, this.compareWith) && !radio.disabled);
 
     if (!first && !checked) {
       return;
@@ -219,7 +219,8 @@ export class RadioGroup implements ComponentInterface {
     if (selectedRadio && !selectedRadio.disabled) {
       const currentValue = this.value;
       const newValue = selectedRadio.value;
-      if (newValue !== currentValue) {
+      const isSelected = isOptionSelected(currentValue, newValue, this.compareWith);
+      if (!isSelected) {
         this.value = newValue;
         this.emitValueChange(ev);
       } else if (this.allowEmptySelection) {
@@ -275,7 +276,8 @@ export class RadioGroup implements ComponentInterface {
       // space bar on top of a selected radio
       if ([' '].includes(ev.key)) {
         const previousValue = this.value;
-        this.value = this.allowEmptySelection && this.value !== undefined ? undefined : current.value;
+        const isSelected = isOptionSelected(this.value, current.value, this.compareWith);
+        this.value = this.allowEmptySelection && isSelected ? undefined : current.value;
         if (previousValue !== this.value || this.allowEmptySelection) {
           /**
            * Value change should only be emitted if the value is different,
diff --git a/core/src/components/radio-group/test/radio-group.spec.tsx b/core/src/components/radio-group/test/radio-group.spec.tsx
index fdd6c644267..cd13bd2acb3 100644
--- a/core/src/components/radio-group/test/radio-group.spec.tsx
+++ b/core/src/components/radio-group/test/radio-group.spec.tsx
@@ -108,4 +108,43 @@ describe('ion-radio-group', () => {
     expect(radios[2].getAttribute('aria-checked')).toBe('true');
     expect(radioGroup.value).toEqual(3);
   });
+
+  it('should allow deselection with compareWith when allowEmptySelection is true', async () => {
+    const page = await newSpecPage({
+      components: [Radio, RadioGroup],
+      template: () => (
+        <ion-radio-group value={{ id: 1 }} compareWith="id" allowEmptySelection={true}>
+          <ion-radio value={{ id: 1 }}>Option #1</ion-radio>
+          <ion-radio value={{ id: 2 }}>Option #2</ion-radio>
+        </ion-radio-group>
+      ),
+    });
+
+    const radioGroup = page.body.querySelector('ion-radio-group')!;
+    const radios = document.querySelectorAll('ion-radio')!;
+
+    expect(radios[0].getAttribute('aria-checked')).toBe('true');
+
+    await radios[0].click();
+    await page.waitForChanges();
+
+    expect(radioGroup.value).toBeUndefined();
+    expect(radios[0].getAttribute('aria-checked')).toBe('false');
+  });
+
+  it('should handle null values safely when compareWith is a property name', async () => {
+    const page = await newSpecPage({
+      components: [Radio, RadioGroup],
+      template: () => (
+        <ion-radio-group value={null} compareWith="id">
+          <ion-radio value={{ id: 1 }}>Option #1</ion-radio>
+          <ion-radio value={{ id: 2 }}>Option #2</ion-radio>
+        </ion-radio-group>
+      ),
+    });
+
+    const radios = document.querySelectorAll('ion-radio')!;
+    expect(radios[0].getAttribute('aria-checked')).toBe('false');
+    expect(radios[1].getAttribute('aria-checked')).toBe('false');
+  });
 });
diff --git a/core/src/utils/forms/compare-with-utils.ts b/core/src/utils/forms/compare-with-utils.ts
index 2ab1fd0237b..b342132920a 100644
--- a/core/src/utils/forms/compare-with-utils.ts
+++ b/core/src/utils/forms/compare-with-utils.ts
@@ -15,7 +15,7 @@ export const compareOptions = (
   if (typeof compareWith === 'function') {
     return compareWith(currentValue, compareValue);
   } else if (typeof compareWith === 'string') {
-    return currentValue[compareWith] === compareValue[compareWith];
+    return currentValue?.[compareWith] !== undefined && currentValue?.[compareWith] === compareValue?.[compareWith];
   } else {
     return Array.isArray(compareValue) ? compareValue.includes(currentValue) : currentValue === compareValue;
   }
@@ -33,7 +33,7 @@ export const isOptionSelected = (
   compareValue: any,
   compareWith?: string | CompareFn | null
 ) => {
-  if (currentValue === undefined) {
+  if (currentValue === undefined || currentValue === null) {
     return false;
   }
   if (Array.isArray(currentValue)) {