diff --git a/dev-packages/node-integration-tests/suites/tracing/http2-server/instrument.mjs b/dev-packages/node-integration-tests/suites/tracing/http2-server/instrument.mjs
new file mode 100644
index 000000000000..46a27dd03b74
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing/http2-server/instrument.mjs
@@ -0,0 +1,9 @@
+import * as Sentry from '@sentry/node';
+import { loggingTransport } from '@sentry-internal/node-integration-tests';
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  tracesSampleRate: 1.0,
+  transport: loggingTransport,
+});
diff --git a/dev-packages/node-integration-tests/suites/tracing/http2-server/scenario-fastify.mjs b/dev-packages/node-integration-tests/suites/tracing/http2-server/scenario-fastify.mjs
new file mode 100644
index 000000000000..d26b38fba250
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing/http2-server/scenario-fastify.mjs
@@ -0,0 +1,26 @@
+import Fastify from 'fastify';
+import http2 from 'node:http2';
+
+async function run() {
+  const app = Fastify({ http2: true });
+
+  app.get('/users/:id', async () => {
+    return { ok: true };
+  });
+
+  await app.listen({ port: 0 });
+
+  const client = http2.connect(`http://localhost:${app.server.address().port}`);
+  await new Promise((resolve, reject) => {
+    const stream = client.request({ ':path': '/users/42' });
+    stream.on('error', reject);
+    stream.on('data', () => {});
+    stream.on('end', resolve);
+    stream.end();
+  });
+
+  client.close();
+  await app.close();
+}
+
+run();
diff --git a/dev-packages/node-integration-tests/suites/tracing/http2-server/scenario.mjs b/dev-packages/node-integration-tests/suites/tracing/http2-server/scenario.mjs
new file mode 100644
index 000000000000..db90c22c2e5c
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing/http2-server/scenario.mjs
@@ -0,0 +1,41 @@
+import * as Sentry from '@sentry/node';
+import http2 from 'node:http2';
+
+const server = http2.createServer((request, response) => {
+  if (request.url === '/error') {
+    Sentry.captureException(new Error('error in http2 handler'));
+    response.statusCode = 500;
+    response.end();
+    return;
+  }
+
+  Sentry.startSpan({ name: 'handler-work' }, () => {});
+  response.end('ok');
+});
+
+function request(client, headers) {
+  return new Promise((resolve, reject) => {
+    const stream = client.request(headers);
+    stream.on('error', reject);
+    stream.on('data', () => {});
+    stream.on('end', resolve);
+    stream.end();
+  });
+}
+
+server.listen(0, async () => {
+  const client = http2.connect(`http://localhost:${server.address().port}`);
+
+  await request(client, {
+    ':path': '/users/42?q=1',
+    'sentry-trace': '12312012123120121231201212312012-1121201211212012-1',
+    baggage: 'sentry-release=2.1.0,sentry-environment=myEnv',
+  });
+  await request(client, {
+    ':path': '/error',
+    'sentry-trace': '45645645645645645645645645645645-4564564564564564-1',
+  });
+
+  client.close();
+  server.close();
+});
diff --git a/dev-packages/node-integration-tests/suites/tracing/http2-server/test.ts b/dev-packages/node-integration-tests/suites/tracing/http2-server/test.ts
new file mode 100644
index 000000000000..3559b8378261
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing/http2-server/test.ts
@@ -0,0 +1,103 @@
+import {
+  HTTP_RESPONSE_STATUS_CODE,
+  NETWORK_PROTOCOL_VERSION,
+  SENTRY_OP,
+  SENTRY_ORIGIN,
+  SERVER_ADDRESS,
+  URL_PATH,
+  URL_QUERY,
+} from '@sentry/conventions/attributes';
+import { HTTP_SERVER } from '@sentry/conventions/op';
+import { afterAll, describe, expect } from 'vitest';
+import { supports } from '../../../utils';
+import { cleanupChildProcesses, createEsmAndCjsTests } from '../../../utils/runner';
+
+describe.runIf(supports({ min: 22, runtimes: ['node'] }))('http2 server', () => {
+  afterAll(() => {
+    cleanupChildProcesses();
+  });
+
+  createEsmAndCjsTests(__dirname, 'scenario.mjs', 'instrument.mjs', (createRunner, test) => {
+    test('isolates compat API requests and continues their traces', async () => {
+      await createRunner()
+        .unordered()
+        .expect({
+          span: container => {
+            const segment = container.items.find(item => item.is_segment);
+            expect(segment?.attributes[URL_PATH]?.value).toBe('/users/42');
+
+            expect(segment).toMatchObject({
+              name: 'GET',
+              trace_id: '12312012123120121231201212312012',
+              parent_span_id: '1121201211212012',
+              status: 'ok',
+            });
+            expect(segment?.attributes).toMatchObject({
+              [SENTRY_OP]: { value: HTTP_SERVER },
+              [SENTRY_ORIGIN]: { value: 'auto.http.http_server' },
+              [URL_QUERY]: { value: 'q=1' },
+              [SERVER_ADDRESS]: { value: 'localhost' },
+              [NETWORK_PROTOCOL_VERSION]: { value: '2.0' },
+              [HTTP_RESPONSE_STATUS_CODE]: { value: 200 },
+            });
+            expect(Object.keys(segment?.attributes ?? {}).filter(key => key.includes(':'))).toEqual([]);
+
+            const child = container.items.find(item => item.name === 'handler-work');
+            expect(child?.parent_span_id).toBe(segment?.span_id);
+          },
+        })
+        .expect({
+          event: event => {
+            expect(event.exception?.values?.[0]?.value).toBe('error in http2 handler');
+            expect(event.request?.url).toMatch(/^http:\/\/localhost:\d+\/error$/);
+            expect(event.request?.method).toBe('GET');
+            expect(Object.keys(event.request?.headers ?? {}).filter(key => key.startsWith(':'))).toEqual([]);
+            expect(event.transaction).toBe('GET /error');
+            expect(event.contexts?.trace?.trace_id).toBe('45645645645645645645645645645645');
+          },
+        })
+        .expect({
+          span: container => {
+            const segment = container.items.find(item => item.is_segment);
+            expect(segment?.attributes[URL_PATH]?.value).toBe('/error');
+            expect(segment?.status).toBe('error');
+            expect(segment?.attributes[HTTP_RESPONSE_STATUS_CODE]?.value).toBe(500);
+            expect(segment?.trace_id).toBe('45645645645645645645645645645645');
+          },
+        })
+        .start()
+        .completed();
+    });
+
+    test('does not trigger HTTP/2 compat API warnings', async () => {
+      await createRunner().ensureNoErrorOutput().start().completed();
+    });
+  });
+
+  createEsmAndCjsTests(__dirname, 'scenario-fastify.mjs', 'instrument.mjs', (createRunner, test) => {
+    test('nests fastify spans under the HTTP/2 server span', async () => {
+      await createRunner()
+        .expect({
+          span: container => {
+            const segment = container.items.find(item => item.is_segment);
+            expect(segment?.name).toBe('GET /users/:id');
+            expect(segment?.attributes).toMatchObject({
+              [SENTRY_OP]: { value: HTTP_SERVER },
+              [NETWORK_PROTOCOL_VERSION]: { value: '2.0' },
+              [HTTP_RESPONSE_STATUS_CODE]: { value: 200 },
+            });
+
+            const fastifySpans = container.items.filter(
+              item => item.attributes[SENTRY_ORIGIN]?.value === 'auto.http.fastify',
+            );
+            expect(fastifySpans.length).toBeGreaterThan(0);
+            for (const span of fastifySpans) {
+              expect(span.trace_id).toBe(segment?.trace_id);
+            }
+          },
+        })
+        .start()
+        .completed();
+    });
+  });
+});
diff --git a/packages/core/src/index.ts b/packages/core/src/index.ts
index 11fd3f6cad1f..1af72cd73655 100644
--- a/packages/core/src/index.ts
+++ b/packages/core/src/index.ts
@@ -147,6 +147,7 @@ export {
   httpRequestToRequestData,
   extractQueryParamsFromUrl,
   headersToDict,
+  getHostFromHeaders,
   httpHeadersToSpanAttributes,
   getContentLengthFromHeaders,
   getMaxBodyByteLength,
diff --git a/packages/core/src/integrations/http/constants.ts b/packages/core/src/integrations/http/constants.ts
index f2af12b00b62..0fad2962451e 100644
--- a/packages/core/src/integrations/http/constants.ts
+++ b/packages/core/src/integrations/http/constants.ts
@@ -1,5 +1,6 @@
 export const LOG_PREFIX = '@sentry/instrumentation-http';
 export const HTTP_ON_CLIENT_REQUEST = 'http.client.request.created';
 export const HTTP_ON_SERVER_REQUEST = 'http.server.request.start';
+export const HTTP2_ON_SERVER_STREAM = 'http2.server.stream.start';
 export type ClientSubscriptionName = typeof HTTP_ON_CLIENT_REQUEST;
-export type ServerSubscriptionName = typeof HTTP_ON_SERVER_REQUEST;
+export type ServerSubscriptionName = typeof HTTP_ON_SERVER_REQUEST | typeof HTTP2_ON_SERVER_STREAM;
diff --git a/packages/core/src/integrations/http/server-subscription.ts b/packages/core/src/integrations/http/server-subscription.ts
index 40298235066b..7acf305b6a5c 100644
--- a/packages/core/src/integrations/http/server-subscription.ts
+++ b/packages/core/src/integrations/http/server-subscription.ts
@@ -19,7 +19,7 @@
 
 import type { ServerSubscriptionName } from './constants';
 type ChannelListener = (message: unknown, name: string | symbol) => void;
-import { HTTP_ON_SERVER_REQUEST } from './constants';
+import { HTTP2_ON_SERVER_STREAM, HTTP_ON_SERVER_REQUEST } from './constants';
 import type { HttpIncomingMessage, HttpInstrumentationOptions, HttpServer, HttpServerResponse } from './types';
 import { DEBUG_BUILD } from '../../debug-build';
 import { debug } from '../../utils/debug-logger';
@@ -30,6 +30,7 @@ import { getClient, getCurrentScope, getIsolationScope, withIsolationScope } fro
 import { hasSpansEnabled } from '../../utils/hasSpansEnabled';
 import {
   getContentLengthFromHeaders,
+  getHostFromHeaders,
   headersToDict,
   httpHeadersToSpanAttributes,
   httpRequestToRequestData,
@@ -280,7 +281,17 @@ export function getHttpServerSubscriptions(options: HttpInstrumentationOptions):
     instrumentServer(effectiveOptions, server);
   };
 
-  return { [HTTP_ON_SERVER_REQUEST]: onHttpServerRequest };
+  // HTTP/2 servers emit the compat API's `'request'` event from inside their
+  // `'stream'` listener, so the same emit wrapper covers them. Servers that
+  // use only the raw `'stream'` API (e.g. gRPC) are not instrumented.
+  const onHttp2ServerStream: ChannelListener = (data: unknown): void => {
+    const server = (data as { stream?: { session?: { server?: HttpServer } } }).stream?.session?.server;
+    if (server) {
+      instrumentServer(effectiveOptions, server);
+    }
+  };
+
+  return { [HTTP_ON_SERVER_REQUEST]: onHttpServerRequest, [HTTP2_ON_SERVER_STREAM]: onHttp2ServerStream };
 }
 
 function buildServerSpanWrap(
@@ -335,7 +346,7 @@ function buildServerSpanWrap(
       const headers = request.headers;
       const userAgent = headers['user-agent'];
       const httpVersion = request.httpVersion;
-      const host = headers.host as undefined | string;
+      const host = getHostFromHeaders(headers);
       const hostname = host?.replace(/^(.*)(:[0-9]{1,5})/, '$1') || 'localhost';
       const scheme = fullUrl.startsWith('https') ? 'https' : 'http';
       const { socket } = request;
@@ -398,7 +409,9 @@ function buildServerSpanWrap(
             isEnded = true;
             // set attributes that come from the response
             span.setAttributes({
-              [HTTP_RESPONSE_STATUS_TEXT]: response.statusMessage?.toUpperCase(),
+              // HTTP/2 has no status text, and reading it emits a process warning.
+              [HTTP_RESPONSE_STATUS_TEXT]:
+                request.httpVersion === '2.0' ? undefined : response.statusMessage?.toUpperCase(),
               [HTTP_RESPONSE_STATUS_CODE]: response.statusCode,
               ...httpHeadersToSpanAttributes(headersToDict(response.headers), dataCollectionOptions, 'response'),
             });
diff --git a/packages/core/src/server.ts b/packages/core/src/server.ts
index 50dfb6639b05..ad4d521f39bc 100644
--- a/packages/core/src/server.ts
+++ b/packages/core/src/server.ts
@@ -62,7 +62,7 @@ export {
   getRequestUrlFromClientRequest,
   getRequestOptions,
 } from './integrations/http/get-request-url';
-export { HTTP_ON_CLIENT_REQUEST, HTTP_ON_SERVER_REQUEST } from './integrations/http/constants';
+export { HTTP_ON_CLIENT_REQUEST, HTTP_ON_SERVER_REQUEST, HTTP2_ON_SERVER_STREAM } from './integrations/http/constants';
 export type {
   HttpInstrumentationOptions,
   HttpClientRequest,
diff --git a/packages/core/src/utils/request.ts b/packages/core/src/utils/request.ts
index 82c7135fb2ac..9527b97d534e 100644
--- a/packages/core/src/utils/request.ts
+++ b/packages/core/src/utils/request.ts
@@ -74,6 +74,10 @@ export function headersToDict(
 
   try {
     Object.entries(reqHeaders).forEach(([key, value]) => {
+      // HTTP/2 pseudo-headers (`:method`, `:path`, ...) are not headers.
+      if (key.startsWith(':')) {
+        return;
+      }
       if (typeof value === 'string') {
         headers[key] = value;
       } else if (typeof value === 'number') {
@@ -87,6 +91,14 @@ export function headersToDict(
   return headers;
 }
 
+/**
+ * The `host` header, or the HTTP/2 `:authority` pseudo-header that replaces it.
+ */
+export function getHostFromHeaders(headers: Record<string, string | string[] | undefined>): string | undefined {
+  const host = headers.host ?? headers[':authority'];
+  return typeof host === 'string' ? host : undefined;
+}
+
 /**
  * Converts a `Request` object that implements the `Web Fetch API` (https://developer.mozilla.org/en-US/docs/Web/API/Headers) into the format that the `RequestData` integration understands.
  */
@@ -213,7 +225,7 @@ export function httpRequestToRequestData(request: {
 
   // Check for x-forwarded-host first, then fall back to host header
   const forwardedHost = typeof headers['x-forwarded-host'] === 'string' ? headers['x-forwarded-host'] : undefined;
-  const host = forwardedHost || (typeof headers.host === 'string' ? headers.host : undefined);
+  const host = forwardedHost || getHostFromHeaders(headers);
 
   // Check for x-forwarded-proto first, then fall back to existing protocol detection
   const forwardedProto = typeof headers['x-forwarded-proto'] === 'string' ? headers['x-forwarded-proto'] : undefined;
diff --git a/packages/core/test/lib/integrations/http/constants.test.ts b/packages/core/test/lib/integrations/http/constants.test.ts
index 6a63e74ba5c6..d666c6167456 100644
--- a/packages/core/test/lib/integrations/http/constants.test.ts
+++ b/packages/core/test/lib/integrations/http/constants.test.ts
@@ -1,5 +1,6 @@
 import { describe, expect, it } from 'vitest';
 import {
+  HTTP2_ON_SERVER_STREAM,
   HTTP_ON_CLIENT_REQUEST,
   HTTP_ON_SERVER_REQUEST,
   LOG_PREFIX,
@@ -17,4 +18,8 @@ describe('http constants', () => {
   it('HTTP_ON_SERVER_REQUEST is the diagnostics-channel name', () => {
     expect(HTTP_ON_SERVER_REQUEST).toBe('http.server.request.start');
   });
+
+  it('HTTP2_ON_SERVER_STREAM is the diagnostics-channel name', () => {
+    expect(HTTP2_ON_SERVER_STREAM).toBe('http2.server.stream.start');
+  });
 });
diff --git a/packages/core/test/lib/integrations/http/server-subscription.test.ts b/packages/core/test/lib/integrations/http/server-subscription.test.ts
index 04c50f221632..68bd2327e304 100644
--- a/packages/core/test/lib/integrations/http/server-subscription.test.ts
+++ b/packages/core/test/lib/integrations/http/server-subscription.test.ts
@@ -1,6 +1,8 @@
 import {
   CLIENT_ADDRESS,
   CLIENT_PORT,
+  HTTP_RESPONSE_STATUS_CODE,
+  HTTP_RESPONSE_STATUS_TEXT,
   NETWORK_LOCAL_ADDRESS,
   NETWORK_LOCAL_PORT,
   NETWORK_PEER_ADDRESS,
@@ -8,13 +10,16 @@ import {
   NETWORK_PROTOCOL_NAME,
   NETWORK_PROTOCOL_VERSION,
   NETWORK_TRANSPORT,
+  SENTRY_OP,
   SERVER_ADDRESS,
   SERVER_PORT,
   URL_FULL,
   URL_PATH,
   URL_QUERY,
 } from '@sentry/conventions/attributes';
+import { HTTP_SERVER } from '@sentry/conventions/op';
 import * as http from 'node:http';
+import * as http2 from 'node:http2';
 import type { AddressInfo } from 'node:net';
 import { afterEach, beforeEach, describe, expect, it, vi } from 'vitest';
 
@@ -22,7 +27,7 @@ import { getIsolationScope } from '../../../../src/currentScopes';
 import { Scope } from '../../../../src/scope';
 import { spanToJSON } from '../../../../src/utils/spanUtils';
 import { setCurrentClient } from '../../../../src/sdk';
-import { HTTP_ON_SERVER_REQUEST } from '../../../../src/integrations/http/constants';
+import { HTTP2_ON_SERVER_STREAM, HTTP_ON_SERVER_REQUEST } from '../../../../src/integrations/http/constants';
 import { getHttpServerSubscriptions } from '../../../../src/integrations/http/server-subscription';
 import type { HttpInstrumentationOptions } from '../../../../src/integrations/http/types';
 import type { Event } from '../../../../src/types/event';
@@ -147,6 +152,42 @@ describe('getHttpServerSubscriptions', () => {
     );
   });
 
+  it('creates a root http.server span for an HTTP/2 compat API request', async () => {
+    const http2Server = http2.createServer((_req, res) => res.end('ok'));
+    server = http2Server as unknown as http.Server;
+    await new Promise<void>(resolve => http2Server.listen(0, '127.0.0.1', () => resolve()));
+
+    const { [HTTP2_ON_SERVER_STREAM]: onServerStream } = getHttpServerSubscriptions({ spans: true });
+    // The listener must run before the compat API's own 'stream' listener, like the channel does.
+    http2Server.prependListener('stream', stream => onServerStream({ stream }, HTTP2_ON_SERVER_STREAM));
+
+    const { port } = http2Server.address() as AddressInfo;
+    const session = http2.connect(`http://127.0.0.1:${port}`);
+    await new Promise<void>((resolve, reject) => {
+      const stream = session.request({ ':path': '/users/42?foo=bar' });
+      stream.on('error', reject);
+      stream.resume();
+      stream.on('end', resolve);
+      stream.end();
+    });
+    session.close();
+
+    const transaction = await waitForTransaction();
+    const data = transaction.contexts?.trace?.data;
+    expect(transaction.transaction).toBe('GET /users/42');
+    expect(data).toEqual(
+      expect.objectContaining({
+        [SENTRY_OP]: HTTP_SERVER,
+        [HTTP_RESPONSE_STATUS_CODE]: 200,
+        [URL_FULL]: `http://127.0.0.1:${port}/users/42?foo=bar`,
+        [SERVER_ADDRESS]: '127.0.0.1',
+        [NETWORK_PROTOCOL_VERSION]: '2.0',
+      }),
+    );
+    expect(data).not.toHaveProperty(HTTP_RESPONSE_STATUS_TEXT);
+    expect(Object.keys(data ?? {}).filter(key => key.includes(':'))).toEqual([]);
+  });
+
   it('prefers the forwarded client over the socket for `client.address`', async () => {
     server = http.createServer((_req, res) => res.end('ok'));
     await new Promise<void>(resolve => server.listen(0, '127.0.0.1', () => resolve()));
diff --git a/packages/core/test/lib/utils/request.test.ts b/packages/core/test/lib/utils/request.test.ts
index 640e7c118f66..30af4105ea51 100644
--- a/packages/core/test/lib/utils/request.test.ts
+++ b/packages/core/test/lib/utils/request.test.ts
@@ -64,6 +64,19 @@ describe('request utils', () => {
         'x-string': 'hello',
       });
     });
+
+    it('drops HTTP/2 pseudo-headers', () => {
+      expect(
+        headersToDict({
+          ':method': 'GET',
+          ':path': '/users',
+          ':authority': 'example.com',
+          'user-agent': 'test',
+        }),
+      ).toEqual({
+        'user-agent': 'test',
+      });
+    });
   });
 
   describe('winterCGRequestToRequestData', () => {
@@ -143,6 +156,27 @@ describe('request utils', () => {
       });
     });
 
+    it('uses the HTTP/2 :authority pseudo-header as the host', () => {
+      const actual = httpRequestToRequestData({
+        method: 'GET',
+        url: '/blabla?xx=a',
+        headers: {
+          ':method': 'GET',
+          ':path': '/blabla?xx=a',
+          ':authority': 'example.com:8443',
+          ':scheme': 'https',
+        },
+        socket: { encrypted: true },
+      });
+
+      expect(actual).toEqual({
+        method: 'GET',
+        url: 'https://example.com:8443/blabla?xx=a',
+        query_string: 'xx=a',
+        headers: {},
+      });
+    });
+
     it('works with relative URL request with host', () => {
       const actual = httpRequestToRequestData({
         url: '/blabla',
diff --git a/packages/node/src/integrations/http/httpServerIntegration.ts b/packages/node/src/integrations/http/httpServerIntegration.ts
index b3c0c939d971..0000e54bc683 100644
--- a/packages/node/src/integrations/http/httpServerIntegration.ts
+++ b/packages/node/src/integrations/http/httpServerIntegration.ts
@@ -3,7 +3,12 @@ import { context, createContextKey, propagation } from '@opentelemetry/api';
 import type { Integration, IntegrationFn } from '@sentry/core';
 import { addNonEnumerableProperty, debug, getClient } from '@sentry/core';
 import type { HttpIncomingMessage, HttpServerResponse } from '@sentry/core/server';
-import { getHttpServerSubscriptions, HTTP_ON_SERVER_REQUEST, recordRequestSession } from '@sentry/core/server';
+import {
+  getHttpServerSubscriptions,
+  HTTP2_ON_SERVER_STREAM,
+  HTTP_ON_SERVER_REQUEST,
+  recordRequestSession,
+} from '@sentry/core/server';
 import { subscribeDiagnosticsChannel } from '@sentry/server-utils';
 import type { RequestEventData } from '@sentry/core';
 import { DEBUG_BUILD } from '../../debug-build';
@@ -138,8 +143,10 @@ const _httpServerIntegration = ((options: HttpServerIntegrationOptions = {}) =>
   return {
     name: INTEGRATION_NAME,
     setupOnce() {
-      const { [HTTP_ON_SERVER_REQUEST]: onHttpServerRequestStart } = getHttpServerSubscriptions(_options);
+      const { [HTTP_ON_SERVER_REQUEST]: onHttpServerRequestStart, [HTTP2_ON_SERVER_STREAM]: onHttp2ServerStreamStart } =
+        getHttpServerSubscriptions(_options);
       subscribeDiagnosticsChannel(HTTP_ON_SERVER_REQUEST, onHttpServerRequestStart);
+      subscribeDiagnosticsChannel(HTTP2_ON_SERVER_STREAM, onHttp2ServerStreamStart);
     },
     afterAllSetup(client) {
       if (DEBUG_BUILD && client.getIntegrationByName('Http')) {
@@ -153,7 +160,7 @@ const _httpServerIntegration = ((options: HttpServerIntegrationOptions = {}) =>
 
 /**
  * This integration handles request isolation, trace continuation and other core Sentry functionality around incoming http requests
- * handled via the node `http` module.
+ * handled via the node `http` module, or via the compat API of the `http2` module.
  *
  * This version uses OpenTelemetry for context propagation and span management.
  *
diff --git a/packages/node/src/integrations/http/httpServerSpansIntegration.ts b/packages/node/src/integrations/http/httpServerSpansIntegration.ts
index 4d896a62485d..e83205354efb 100644
--- a/packages/node/src/integrations/http/httpServerSpansIntegration.ts
+++ b/packages/node/src/integrations/http/httpServerSpansIntegration.ts
@@ -42,6 +42,7 @@ import {
   getSpanStatusFromHttpCode,
   httpHeadersToSpanAttributes,
   getContentLengthFromHeaders,
+  getHostFromHeaders,
   parseStringToURLObject,
   SPAN_STATUS_ERROR,
   stripUrlQueryAndFragment,
@@ -153,7 +154,7 @@ const _httpServerSpansIntegration = ((options: HttpServerSpansIntegrationOptions
           const headers = request.headers;
           const userAgent = headers['user-agent'];
           const httpVersion = request.httpVersion;
-          const host = headers.host as string | undefined;
+          const host = getHostFromHeaders(headers);
           const hostname = host?.replace(/^(.*)(:[0-9]{1,5})/, '$1') || 'localhost';
 
           const scheme = fullUrl.startsWith('https') ? 'https' : 'http';
@@ -360,11 +361,12 @@ function getIncomingRequestAttributesOnResponse(
   // take socket from the request,
   // since it may be detached from the response object in keep-alive mode
   const { socket } = request;
-  const { statusCode, statusMessage } = response;
+  const { statusCode } = response;
 
   const newAttributes: SpanAttributes = {
     [HTTP_RESPONSE_STATUS_CODE]: statusCode,
-    [HTTP_RESPONSE_STATUS_TEXT]: statusMessage?.toUpperCase(),
+    // HTTP/2 has no status text, and reading it emits a process warning.
+    [HTTP_RESPONSE_STATUS_TEXT]: request.httpVersion === '2.0' ? undefined : response.statusMessage?.toUpperCase(),
   };
 
   // `client.address` is the originating client, so a forwarding header wins over the socket, which