diff --git a/packages/cloudflare/src/wrapMethodWithSentry.ts b/packages/cloudflare/src/wrapMethodWithSentry.ts
index 3c719e7da4b1..7bc01940286a 100644
--- a/packages/cloudflare/src/wrapMethodWithSentry.ts
+++ b/packages/cloudflare/src/wrapMethodWithSentry.ts
@@ -68,13 +68,17 @@ export function wrapMethodWithSentry<T extends OriginalMethod>(
 
         const waitUntil = context?.waitUntil?.bind?.(context);
 
-        const currentClient = scope.getClient();
-        if (!currentClient) {
+        let currentClient = scope.getClient();
+        // Check if client exists AND is still usable (transport not disposed)
+        // This handles the case where a previous handler disposed the client
+        // but the scope still holds a reference to it (e.g., alarm handlers in Durable Objects)
+        if (!currentClient || !currentClient.getTransport()) {
           const client = init({ ...wrapperOptions.options, ctx: context as unknown as ExecutionContext | undefined });
           scope.setClient(client);
+          currentClient = client;
         }
 
-        const clientToDispose = currentClient || scope.getClient();
+        const clientToDispose = currentClient;
 
         if (!wrapperOptions.spanName) {
           try {
diff --git a/packages/cloudflare/test/wrapMethodWithSentry.test.ts b/packages/cloudflare/test/wrapMethodWithSentry.test.ts
index a7e73a83cd39..c831bd01a6bb 100644
--- a/packages/cloudflare/test/wrapMethodWithSentry.test.ts
+++ b/packages/cloudflare/test/wrapMethodWithSentry.test.ts
@@ -1,25 +1,31 @@
 import * as sentryCore from '@sentry/core';
 import { afterEach, beforeEach, describe, expect, it, vi } from 'vitest';
 import { isInstrumented } from '../src/instrument';
+import * as sdk from '../src/sdk';
 import { wrapMethodWithSentry } from '../src/wrapMethodWithSentry';
 
-// Mock the SDK init to avoid actual SDK initialization
-vi.mock('../src/sdk', () => ({
-  init: vi.fn(() => ({
+function createMockClient(hasTransport: boolean = true) {
+  return {
     getOptions: () => ({}),
     on: vi.fn(),
     dispose: vi.fn(),
-  })),
+    getTransport: vi.fn().mockReturnValue(hasTransport ? { send: vi.fn() } : undefined),
+  };
+}
+
+// Mock the SDK init to avoid actual SDK initialization
+vi.mock('../src/sdk', () => ({
+  init: vi.fn(() => createMockClient(true)),
 }));
 
 // Mock sentry/core functions
 vi.mock('@sentry/core', async importOriginal => {
-  const actual = await importOriginal();
+  const actual = await importOriginal<object>();
   return {
     ...actual,
     getClient: vi.fn(),
-    withIsolationScope: vi.fn((callback: (scope: any) => any) => callback(createMockScope())),
-    withScope: vi.fn((callback: (scope: any) => any) => callback(createMockScope())),
+    withIsolationScope: vi.fn((callback: (scope: unknown) => unknown) => callback(createMockScope())),
+    withScope: vi.fn((callback: (scope: unknown) => unknown) => callback(createMockScope())),
     startSpan: vi.fn((opts, callback) => callback(createMockSpan())),
     captureException: vi.fn(),
     flush: vi.fn().mockResolvedValue(true),
@@ -27,6 +33,8 @@ vi.mock('@sentry/core', async importOriginal => {
   };
 });
 
+const mockedWithIsolationScope = vi.mocked(sentryCore.withIsolationScope);
+
 function createMockScope() {
   return {
     getClient: vi.fn(),
@@ -307,4 +315,90 @@ describe('wrapMethodWithSentry', () => {
       expect(handler.mock.instances[0]).toBe(thisArg);
     });
   });
+
+  describe('client re-initialization', () => {
+    it('creates a new client when scope has no client', async () => {
+      const scope = new sentryCore.Scope();
+
+      mockedWithIsolationScope.mockImplementation(vi.fn(callback => callback(scope)));
+
+      const spyClient = vi.spyOn(scope, 'setClient');
+      const handler = vi.fn().mockResolvedValue('result');
+      const options = {
+        options: { dsn: 'https://test@sentry.io/123' },
+        context: createMockContext(),
+      };
+
+      const wrapped = wrapMethodWithSentry(options, handler);
+
+      await wrapped();
+
+      expect(sdk.init).toHaveBeenCalledWith(
+        expect.objectContaining({
+          dsn: 'https://test@sentry.io/123',
+        }),
+      );
+      expect(spyClient).toHaveBeenCalled();
+    });
+
+    it('creates a new client when existing client has no transport (disposed)', async () => {
+      const disposedClient = {
+        getOptions: () => ({}),
+        on: vi.fn(),
+        dispose: vi.fn(),
+        getTransport: vi.fn().mockReturnValue(undefined),
+      } as unknown as sentryCore.Client;
+
+      const scope = new sentryCore.Scope();
+
+      scope.setClient(disposedClient);
+      mockedWithIsolationScope.mockImplementation(vi.fn(callback => callback(scope)));
+
+      const spyClient = vi.spyOn(scope, 'setClient');
+      const handler = vi.fn().mockResolvedValue('result');
+      const options = {
+        options: { dsn: 'https://test@sentry.io/123' },
+        context: createMockContext(),
+      };
+
+      const wrapped = wrapMethodWithSentry(options, handler);
+      await wrapped();
+
+      expect(sdk.init).toHaveBeenCalledWith(
+        expect.objectContaining({
+          dsn: 'https://test@sentry.io/123',
+        }),
+      );
+      expect(spyClient).toHaveBeenCalled();
+    });
+
+    it('does not create a new client when existing client has valid transport', async () => {
+      const validClient = {
+        getOptions: () => ({}),
+        on: vi.fn(),
+        dispose: vi.fn(),
+        getTransport: vi.fn().mockReturnValue({ send: vi.fn() }),
+      } as unknown as sentryCore.Client;
+
+      const scope = new sentryCore.Scope();
+
+      scope.setClient(validClient);
+      mockedWithIsolationScope.mockImplementation(vi.fn(callback => callback(scope)));
+      vi.mocked(sdk.init).mockClear();
+
+      const spyClient = vi.spyOn(scope, 'setClient');
+      const handler = vi.fn().mockResolvedValue('result');
+      const options = {
+        options: { dsn: 'https://test@sentry.io/123' },
+        context: createMockContext(),
+      };
+
+      const wrapped = wrapMethodWithSentry(options, handler);
+
+      await wrapped();
+
+      expect(sdk.init).not.toHaveBeenCalled();
+      expect(spyClient).not.toHaveBeenCalled();
+    });
+  });
 });