diff --git a/.github/workflows/ci-scripts-build.yml b/.github/workflows/ci-scripts-build.yml
index f77157b..c400628 100644
--- a/.github/workflows/ci-scripts-build.yml
+++ b/.github/workflows/ci-scripts-build.yml
@@ -15,52 +15,93 @@ jobs:
     runs-on: ${{ matrix.os }}
     # Set environment variables from matrix parameters
     env:
+      CMP: ${{ matrix.cmp }}
+      BCFG: ${{ matrix.configuration }}
       BASE: ${{ matrix.base }}
       PROF: ${{ matrix.profile }}
       EXTRA: ${{ matrix.extra }}
       TEST: ${{ matrix.test }}
+      VV: "1"
 
     strategy:
       fail-fast: false
       matrix:
         include:
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "7.0"
             python: "2.7"
             profile: deb8
             test: yes
 
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "7.0"
             python: "2.7"
             profile: deb8
             test: yes
 
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "7.0"
             python: "3.7"
             profile: deb10
             test: yes
 
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "7.0"
             python: "3.8"
             profile: latest
             test: yes
 
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "7.0"
             python: "3.9"
             profile: latest
             test: yes
 
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
+            base: "7.0"
+            python: "3.10"
+            profile: latest
+            test: yes
+
+          - os: macos-latest
+            cmp: gcc
+            configuration: default
+            base: "7.0"
+            python: "3.10"
+            profile: latest
+            test: yes
+
+          - os: windows-latest
+            cmp: vs2019
+            configuration: debug
+            base: "7.0"
+            python: "3.10"
+            profile: latest
+            test: yes
+
+          - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "3.15"
             python: "2.7"
             profile: deb8
             test: yes
 
           - os: ubuntu-latest
+            cmp: gcc
+            configuration: default
             base: "3.14"
             python: "2.7"
             profile: deb8
@@ -74,6 +115,7 @@ jobs:
       with:
         python-version: ${{ matrix.python }}
     - name: More Setup Python
+      shell: bash
       run: |
         python --version
         python -m pip --version
@@ -83,6 +125,13 @@ jobs:
         EOF
         echo === configure/CONFIG_SITE.local ===
         cat configure/CONFIG_SITE.local
+    - name: makehelper.py
+      run: python makehelper.py
+    - name: DSOs
+      shell: bash
+      run: find ${Python_ROOT_DIR} -name '*.dll' -o -name '*.so' -o -name '*.dylib'
+    - name: get_config_vars
+      run: python -c 'from sysconfig import get_config_vars; from pprint import pprint; pprint(get_config_vars())'
     - name: Prepare and compile dependencies
       run: python .ci/cue.py prepare
     - name: Build main module
diff --git a/devsupApp/src/Makefile b/devsupApp/src/Makefile
index 3a26547..4968e84 100644
--- a/devsupApp/src/Makefile
+++ b/devsupApp/src/Makefile
@@ -29,6 +29,8 @@ _dbapi_SRCS += utest.c
 _dbapi_SRCS += pyDevSupCommon_registerRecordDeviceDriver.cpp
 
 _dbapi_LIBS += $(EPICS_BASE_IOC_LIBS)
+_dbapi_SYS_LIBS_WIN32 += python$(PY_LD_VER)
+_dbapi_SYS_LIBS_WIN32 += ws2_32 Advapi32 Dbghelp
 
 PY += devsup/__init__.py
 PY += devsup/db.py
@@ -61,7 +63,7 @@ pyconfig:
 
 ifneq (,$(T_A))
 nose:
-	PYTHONPATH="${PYTHONPATH}:$(abspath $(TOP))/python$(PY_LD_VER)/$(EPICS_HOST_ARCH)" $(PYTHON) -m nose -P devsup $(NOSEFLAGS)
+	PYTHONPATH="${PYTHONPATH}:$(abspath $(TOP))/python$(PY_LD_VER)/$(EPICS_HOST_ARCH)" $(PYTHON) -m nose2 -v devsup $(NOSEFLAGS)
 
 # bounce back down to the sphinx generated Makefile
 # aren't Makefiles fun...
diff --git a/devsupApp/src/dbapi.c b/devsupApp/src/dbapi.c
index 2dab153..f859cd6 100644
--- a/devsupApp/src/dbapi.c
+++ b/devsupApp/src/dbapi.c
@@ -278,7 +278,7 @@ static struct PyMethodDef dbapimethod[] = {
      "Execute IOC shell script or command"},
     {"dbReadDatabase", (PyCFunction)py_dbReadDatabase, METH_VARARGS|METH_KEYWORDS,
      "Load EPICS database file"},
-    {"iocInit", (PyCFunction)py_iocInit, METH_NOARGS,
+    {"iocInit", (PyCFunction)py_iocInit, METH_VARARGS|METH_KEYWORDS,
      "Initialize IOC"},
     {"_dbd_setup", (PyCFunction)pyDBD_setup, METH_NOARGS, ""},
     {"_dbd_rrd_base", (PyCFunction)py_pyDevSupCommon, METH_NOARGS, ""},
diff --git a/devsupApp/src/dbdset.c b/devsupApp/src/dbdset.c
index 68d76e4..954d0c5 100644
--- a/devsupApp/src/dbdset.c
+++ b/devsupApp/src/dbdset.c
@@ -24,6 +24,7 @@
 #include <aSubRecord.h>
 
 #include "pydevsup.h"
+#include <shareLib.h>
 
 static int inshutdown;
 
@@ -449,7 +450,8 @@ static long python_asub(aSubRecord* prec)
 }
 
 /* uglyness to detect aSubRecord */
-extern rset* pvar_rset_aSubRSET;
+epicsShareExtern
+rset* pvar_rset_aSubRSET;
 
 int isPyRecord(dbCommon *prec)
 {
diff --git a/makehelper.py b/makehelper.py
index ef36d63..ed0c0a0 100644
--- a/makehelper.py
+++ b/makehelper.py
@@ -14,7 +14,6 @@
 from __future__ import print_function
 
 import sys
-import errno
 import os
 
 if len(sys.argv)<2:
@@ -26,10 +25,18 @@
         pass
     out = open(sys.argv[1], 'w')
 
-from distutils.sysconfig import get_config_var, get_python_inc
+from sysconfig import get_config_var
+try:
+    from distutils.sysconfig import get_python_inc
+except ImportError:
+    def get_python_inc():
+        return get_config_var('INCLUDEPY') or ''
 
 incdirs = [get_python_inc()]
-libdir = get_config_var('LIBDIR') or ''
+libdirs = [
+    get_config_var('LIBDIR') or get_config_var('LIBDEST') or '',
+    get_config_var('BINDIR') or '',
+]
 
 have_np='NO'
 try:
@@ -39,8 +46,8 @@
 except ImportError:
     pass
 
-print('TARGET_CFLAGS +=',get_config_var('BASECFLAGS'), file=out)
-print('TARGET_CXXFLAGS +=',get_config_var('BASECFLAGS'), file=out)
+print('TARGET_CFLAGS +=',get_config_var('BASECFLAGS') or '', file=out)
+print('TARGET_CXXFLAGS +=',get_config_var('BASECFLAGS') or '', file=out)
 
 print('PY_VER :=',get_config_var('VERSION'), file=out)
 ldver = get_config_var('LDVERSION')
@@ -50,7 +57,8 @@
         ldver = ldver+'_d'
 print('PY_LD_VER :=',ldver, file=out)
 print('PY_INCDIRS :=',' '.join(incdirs), file=out)
-print('PY_LIBDIRS :=',libdir, file=out)
+print('PY_LIBDIRS :=',' '.join(libdirs), file=out)
+print('PY_LDLIBS :=', get_config_var('BLDLIBRARY') or '', file=out)
 print('HAVE_NUMPY :=',have_np, file=out)
 
 try:
diff --git a/requirements-deb10.txt b/requirements-deb10.txt
index 382bf56..91aeff2 100644
--- a/requirements-deb10.txt
+++ b/requirements-deb10.txt
@@ -1,2 +1,3 @@
 numpy==1.16.2
-nose==1.3.7
+#nose==1.3.7
+nose2
diff --git a/requirements-deb7.txt b/requirements-deb7.txt
index 84d50dc..b143719 100644
--- a/requirements-deb7.txt
+++ b/requirements-deb7.txt
@@ -1,2 +1,3 @@
 numpy==1.6.2
-nose==1.1.2
+#nose==1.1.2
+nose2
diff --git a/requirements-deb8.txt b/requirements-deb8.txt
index 135f812..46ac10a 100644
--- a/requirements-deb8.txt
+++ b/requirements-deb8.txt
@@ -1,2 +1,3 @@
 numpy==1.8.2
-nose==1.3.4
+#nose==1.3.4
+nose2
diff --git a/requirements-deb9.txt b/requirements-deb9.txt
index d3e0a04..90d1c74 100644
--- a/requirements-deb9.txt
+++ b/requirements-deb9.txt
@@ -1,2 +1,3 @@
 numpy==1.12.1
-nose==1.3.7
+#nose==1.3.7
+nose2
diff --git a/requirements-latest.txt b/requirements-latest.txt
index 02e0c84..99ce0ab 100644
--- a/requirements-latest.txt
+++ b/requirements-latest.txt
@@ -1,2 +1,2 @@
 numpy
-nose
+nose2