diff --git a/README.md b/README.md
index 1a7ef855..de7a77c6 100644
--- a/README.md
+++ b/README.md
@@ -37,7 +37,7 @@ export PATH="$PATH:$HOME/go/bin"
 - **Git**: For version control and worktree management
 - **Tmux**: For terminal session management
 - **Go**: For installing
-- **Your AI tool of choice**: Such as `claude`, `codex`, etc.
+- **Your AI tool of choice**: Such as `claude`, `codex`, `copilot`, etc.
 
 ## Configuration
 
@@ -194,6 +194,15 @@ uzi reset
 uzi prompt --agents=claude:2,aider:2,cursor:1 "Refactor the authentication system"
 ```
 
+**Using GitHub Copilot CLI:**
+
+The `copilot` agent is launched non-interactively with `copilot -s --allow-all-tools --no-ask-user -p "<prompt>"`, so it runs autonomously without stopping for tool or trust prompts. Set `COPILOT_MODEL` to pick a model (passed through as `--model`).
+
+```bash
+uzi prompt --agents=copilot:3 "Add input validation to the signup form"
+COPILOT_MODEL=claude-sonnet-4.5 uzi prompt --agents=copilot:1 "Fix the failing tests"
+```
+
 **Using random agent names:**
 
 ```bash
diff --git a/cmd/prompt/prompt.go b/cmd/prompt/prompt.go
index e364c25f..91ff973f 100644
--- a/cmd/prompt/prompt.go
+++ b/cmd/prompt/prompt.go
@@ -74,6 +74,24 @@ func parseAgents(agentsStr string) (map[string]AgentConfig, error) {
 	return agentConfigs, nil
 }
 
+// buildAgentCommand returns the command prefix used to invoke an agent. Most
+// agents are launched as `<agent> "<prompt>"`, but GitHub Copilot needs its
+// non-interactive flags so it never blocks on a permission or trust prompt. The
+// trailing prompt is still appended by the tmux send-keys template, so the
+// returned command ends with -p for copilot. An optional model is read from
+// COPILOT_MODEL and passed through with --model.
+func buildAgentCommand(commandToUse string) string {
+	if commandToUse != "copilot" {
+		return commandToUse
+	}
+
+	cmd := "copilot -s --allow-all-tools --no-ask-user"
+	if model := strings.TrimSpace(os.Getenv("COPILOT_MODEL")); model != "" {
+		cmd += " --model " + model
+	}
+	return cmd + " -p"
+}
+
 // isPortAvailable checks if a port is available for use
 func isPortAvailable(port int) bool {
 	address := fmt.Sprintf(":%d", port)
@@ -237,7 +255,7 @@ func executePrompt(ctx context.Context, args []string) error {
 				}
 
 				// Always run send-keys command to the agent pane
-				tmuxCmd := fmt.Sprintf("tmux send-keys -t %s:agent '%s \"%%s\"' C-m", sessionName, commandToUse)
+				tmuxCmd := fmt.Sprintf("tmux send-keys -t %s:agent '%s \"%%s\"' C-m", sessionName, buildAgentCommand(commandToUse))
 				tmuxCmdExec := exec.CommandContext(ctx, "sh", "-c", fmt.Sprintf(tmuxCmd, promptText))
 				tmuxCmdExec.Dir = worktreePath
 				if err := tmuxCmdExec.Run(); err != nil {
@@ -302,7 +320,7 @@ func executePrompt(ctx context.Context, args []string) error {
 			assignedPorts = append(assignedPorts, selectedPort)
 
 			// Always run send-keys command to the agent pane
-			tmuxCmd := fmt.Sprintf("tmux send-keys -t %s:agent '%s \"%%s\"' C-m", sessionName, commandToUse)
+			tmuxCmd := fmt.Sprintf("tmux send-keys -t %s:agent '%s \"%%s\"' C-m", sessionName, buildAgentCommand(commandToUse))
 			tmuxCmdExec := exec.CommandContext(ctx, "sh", "-c", fmt.Sprintf(tmuxCmd, promptText))
 			tmuxCmdExec.Dir = worktreePath
 			if err := tmuxCmdExec.Run(); err != nil {
diff --git a/cmd/prompt/prompt_test.go b/cmd/prompt/prompt_test.go
new file mode 100644
index 00000000..684d0bb5
--- /dev/null
+++ b/cmd/prompt/prompt_test.go
@@ -0,0 +1,53 @@
+package prompt
+
+import "testing"
+
+func TestBuildAgentCommand(t *testing.T) {
+	t.Setenv("COPILOT_MODEL", "")
+
+	cases := []struct {
+		name    string
+		command string
+		want    string
+	}{
+		{"claude passthrough", "claude", "claude"},
+		{"codex passthrough", "codex", "codex"},
+		{"aider passthrough", "aider", "aider"},
+		{"copilot non-interactive", "copilot", "copilot -s --allow-all-tools --no-ask-user -p"},
+	}
+
+	for _, tc := range cases {
+		t.Run(tc.name, func(t *testing.T) {
+			if got := buildAgentCommand(tc.command); got != tc.want {
+				t.Errorf("buildAgentCommand(%q) = %q, want %q", tc.command, got, tc.want)
+			}
+		})
+	}
+}
+
+func TestBuildAgentCommandWithModel(t *testing.T) {
+	t.Setenv("COPILOT_MODEL", "claude-sonnet-4.5")
+
+	want := "copilot -s --allow-all-tools --no-ask-user --model claude-sonnet-4.5 -p"
+	if got := buildAgentCommand("copilot"); got != want {
+		t.Errorf("buildAgentCommand(\"copilot\") = %q, want %q", got, want)
+	}
+
+	if got := buildAgentCommand("claude"); got != "claude" {
+		t.Errorf("model should not affect non-copilot agents, got %q", got)
+	}
+}
+
+func TestParseAgents(t *testing.T) {
+	configs, err := parseAgents("copilot:2,claude:1")
+	if err != nil {
+		t.Fatalf("parseAgents returned error: %v", err)
+	}
+
+	if got := configs["copilot"]; got.Command != "copilot" || got.Count != 2 {
+		t.Errorf("copilot config = %+v, want {copilot 2}", got)
+	}
+	if got := configs["claude"]; got.Command != "claude" || got.Count != 1 {
+		t.Errorf("claude config = %+v, want {claude 1}", got)
+	}
+}
diff --git a/cmd/watch/auto.go b/cmd/watch/auto.go
index 0ac40485..585979ee 100644
--- a/cmd/watch/auto.go
+++ b/cmd/watch/auto.go
@@ -75,8 +75,9 @@ func (aw *AgentWatcher) hasUpdated(sessionName string) (bool, bool, error) {
 	// Check for specific prompts that need auto-enter
 	hasPrompt := false
 
-	// Check for Claude trust prompt
-	if strings.Contains(content, "Do you trust the files in this folder?") {
+	// Check for Claude trust prompt (GitHub Copilot uses the same wording)
+	if strings.Contains(content, "Do you trust the files in this folder?") ||
+		strings.Contains(content, "Confirm folder trust") {
 		hasPrompt = true
 	}