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@@ -51,6 +51,11 @@ <h2>Overview</h2>
       <td><b>Title</b></td>
       <td><b>Date</b></td>
   </tr>
+  <tr>
+      <td>Maxwell Cole</td>
+      <td><a href="#fy267">First digital biophysical model of the entire human cardiovascular system</a></td>
+      <td>08/27/2025</td>
+  </tr>
   <tr>
       <td>Michael L Norman </td>
       <td><a href="#fy266">Introducing Enzo-E, an extreme scale AMR radiation hydrodynamic cosmology code built on Charm++</a></td>
@@ -149,6 +154,45 @@ <h2>Overview</h2>
 </table>
 
 <h2>Talks</h2>
+
+
+<div id="fy267"></div>
+<h3>First digital biophysical model of the entire human cardiovascular system</h3>
+Speaker: Maxwell Cole<br>
+University of California, San Diego<br><br>
+
+Abstract:
+<p>
+Cardiovascular disease is the leading cause of death worldwide. While substantial progress
+has been made in understanding and managing these diseases, current strategies have not
+been sufficient to reverse increasing incidence and burden. A potential research solution is
+the cardiovascular digital twin, a virtual replica of the human circulatory system. However,
+a digital twin of the entire human vasculature has never been accomplished due to the large
+computational costs. The goal of this work was to determine the feasibility of a CVDT that
+includes modeling all vessels in the human body, including physiologically-relevant biophysical
+mechanisms. We used a fractal algorithm to generate all 34 billion blood vessels of the
+human body, and calculated the time-dependent blood flow using an integrated heart model.
+We included nitric-oxide-mediated vasodilation, as well as vessel deformation and rupture
+using peridynamics. To test the computational feasibility, we determined the complexity,
+parallel scalability, and the amount of resources required, including execution time, memory
+usage, and floating-point operations. We found the CVDT to be computationally feasible,
+with all simulations requiring fewer than 30 minutes of wall-clock time. With further computational
+optimizations and biophysical improvements, this model has potential to shift
+the change the paradigm of cardiovascular research and patient care.
+</p>
+
+Bio:
+<p>
+Dr. Maxwell Cole recently earned his Ph.D. in physics from Louisiana State University,
+where he worked on developing the first digital twin of the entire human cardiovascular
+system. His research utilized high-performance computing to simulate biophysical processes
+at a systemic scale, aiming to create new computational tools that illuminate how diseases
+develop and localize in the body. Dr. Cole is now a medical physics resident at the University
+of California, San Diego, leveraging physics to advance patient care through improved
+prevention, diagnosis, and treatment.
+</p>
+
+
 <div id="fy266"></div>
 <h3>Introducing Enzo-E, an extreme scale AMR radiation hydrodynamic cosmology code built on Charm++</h3>
 Speaker: Michael L Norman<br>
@@ -182,7 +226,7 @@ <h3>AI for code development at LANL</h3>
 
 <div id="fy262"></div>
 <h3>Shedding Light on Interaction Binaries: Radiation Hydrodynamics with Octo-Tiger</h3>
-Speaker: Dominic Marcello<br>
+Speaker: Dominic Marcello <a href="https://www.linkedin.com/in/dominic-marcello-71381718b/"><i class="fa fa-linkedin-square" style="font-size:18px"></i></a><br>
 Center for Computation & Technology<br>
 Louisiana State University<br><br>