diff --git a/src/components/Tooltip/anchor-registry.ts b/src/components/Tooltip/anchor-registry.ts
index ccab81e7..447acf4b 100644
--- a/src/components/Tooltip/anchor-registry.ts
+++ b/src/components/Tooltip/anchor-registry.ts
@@ -1,3 +1,5 @@
+import parseDataTooltipIdSelector from '../../utils/parse-data-tooltip-id-selector'
+
 type AnchorRegistrySubscriber = (anchors: Element[], error: Error | null) => void
 
 type AnchorRegistryEntry = {
@@ -16,15 +18,6 @@ const registry = new Map<string, AnchorRegistryEntry>()
 
 let documentObserver: MutationObserver | null = null
 
-/**
- * Extract a tooltip ID from a simple `[data-tooltip-id='value']` selector.
- * Returns null for complex or custom selectors.
- */
-function extractTooltipId(selector: string): string | null {
-  const match = selector.match(/^\[data-tooltip-id=(['"])((?:\\.|(?!\1).)*)\1\]$/)
-  return match ? match[2].replace(/\\(['"])/g, '$1') : null
-}
-
 function areAnchorListsEqual(left: Element[], right: Element[]) {
   if (left.length !== right.length) {
     return false
@@ -222,7 +215,7 @@ export function subscribeAnchorSelector(selector: string, subscriber: AnchorRegi
       anchors: initialState.anchors,
       error: initialState.error,
       subscribers: new Set(),
-      tooltipId: extractTooltipId(selector),
+      tooltipId: parseDataTooltipIdSelector(selector),
     }
     registry.set(selector, entry)
   }
diff --git a/src/test/escaped-anchor-selectors.spec.js b/src/test/escaped-anchor-selectors.spec.js
new file mode 100644
index 00000000..10ef0f1b
--- /dev/null
+++ b/src/test/escaped-anchor-selectors.spec.js
@@ -0,0 +1,53 @@
+import { subscribeAnchorSelector, resetAnchorRegistry } from '../components/Tooltip/anchor-registry'
+import { installMockMutationObserver } from './mutation-observer-test-utils'
+import parseDataTooltipIdSelector from '../utils/parse-data-tooltip-id-selector'
+import { act } from '@testing-library/react'
+
+describe('escaped anchor selectors', () => {
+  let controller
+  beforeEach(() => {
+    resetAnchorRegistry()
+    document.body.innerHTML = ''
+    controller = installMockMutationObserver()
+  })
+  afterEach(() => {
+    resetAnchorRegistry()
+    controller.restore()
+    document.body.innerHTML = ''
+  })
+
+  test('uses native selector matching for hexadecimal and backslash escapes', () => {
+    expect(parseDataTooltipIdSelector("[data-tooltip-id='\\61 nchor']")).toBeNull()
+    expect(parseDataTooltipIdSelector("[data-tooltip-id='a\\\\b']")).toBeNull()
+    expect(parseDataTooltipIdSelector("[data-tooltip-id='a\\'b']")).toBe("a'b")
+  })
+
+  test.each([
+    ["[data-tooltip-id='\\61 nchor']", 'anchor'],
+    ["[data-tooltip-id='a\\\\b']", 'a\\b'],
+  ])(
+    'updates escaped selector %s when more than four selectors are registered',
+    async (selector, id) => {
+      const subscriber = jest.fn()
+      subscribeAnchorSelector(selector, subscriber)
+      for (let i = 0; i < 4; i++) {
+        subscribeAnchorSelector(`[data-tooltip-id='other-${i}']`, jest.fn())
+      }
+      const anchor = document.createElement('button')
+      anchor.dataset.tooltipId = id
+      document.body.appendChild(anchor)
+      expect(document.querySelector(selector)).toBe(anchor)
+      controller.triggerAll([{ type: 'childList', addedNodes: [anchor], removedNodes: [] }])
+      await act(async () => {
+        await new Promise((resolve) => setTimeout(resolve, 32))
+      })
+      expect(subscriber).toHaveBeenLastCalledWith([anchor], null)
+      anchor.removeAttribute('data-tooltip-id')
+      controller.triggerAll([{ type: 'attributes', target: anchor, oldValue: id }])
+      await act(async () => {
+        await new Promise((resolve) => setTimeout(resolve, 32))
+      })
+      expect(subscriber).toHaveBeenLastCalledWith([], null)
+    },
+  )
+})
diff --git a/src/utils/parse-data-tooltip-id-selector.ts b/src/utils/parse-data-tooltip-id-selector.ts
index 5d6b4ae9..b00e5d99 100644
--- a/src/utils/parse-data-tooltip-id-selector.ts
+++ b/src/utils/parse-data-tooltip-id-selector.ts
@@ -1,7 +1,11 @@
 function parseDataTooltipIdSelector(selector: string) {
+  // Extracts the quote character and raw attribute value from a [data-tooltip-id=...] selector.
   const match = selector.match(/^\[data-tooltip-id=(['"])((?:\\.|(?!\1).)*)\1\]$/)
 
-  if (!match) {
+  // Detects escapes other than quotes that require native selector fallback.
+  const unsupportedEscapeRegex = /\\(?!['"])/
+
+  if (!match || unsupportedEscapeRegex.test(match[2])) {
     return null
   }