diff --git a/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/EndHandlerWrapper.java b/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/EndHandlerWrapper.java
index a71584b11a7..fd4a042edf8 100644
--- a/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/EndHandlerWrapper.java
+++ b/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/EndHandlerWrapper.java
@@ -1,9 +1,5 @@
 package datadog.trace.instrumentation.vertx_4_0.server;
 
-import static datadog.trace.instrumentation.vertx_4_0.server.RouteHandlerWrapper.HANDLER_SPAN_CONTEXT_KEY;
-import static datadog.trace.instrumentation.vertx_4_0.server.VertxDecorator.DECORATE;
-
-import datadog.trace.bootstrap.instrumentation.api.AgentSpan;
 import io.vertx.core.Handler;
 import io.vertx.ext.web.RoutingContext;
 
@@ -18,16 +14,12 @@ public class EndHandlerWrapper implements Handler<Void> {
 
   @Override
   public void handle(final Void event) {
-    AgentSpan span = routingContext.get(HANDLER_SPAN_CONTEXT_KEY);
     try {
       if (actual != null) {
         actual.handle(event);
       }
     } finally {
-      if (span != null) {
-        DECORATE.onResponse(span, routingContext.response());
-        span.finish();
-      }
+      RouteHandlerWrapper.finishHandlerSpan(routingContext);
     }
   }
 }
diff --git a/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/RouteHandlerWrapper.java b/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/RouteHandlerWrapper.java
index 8706f816e1c..19b344b75f6 100644
--- a/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/RouteHandlerWrapper.java
+++ b/dd-java-agent/instrumentation/vertx/vertx-web/vertx-web-4.0/src/main/java/datadog/trace/instrumentation/vertx_4_0/server/RouteHandlerWrapper.java
@@ -44,6 +44,16 @@ public void handle(final RoutingContext routingContext) {
         routingContext.put(HANDLER_SPAN_CONTEXT_KEY, span);
 
         routingContext.response().endHandler(new EndHandlerWrapper(routingContext));
+        // Fallback finish path: HttpServerResponse.endHandler is silently skipped
+        // by Vert.x's Http1xServerResponse.end() when the underlying connection
+        // has already closed (Http1xServerResponse#end gates `endHandler.handle()`
+        // behind `!closed`). This happens in synthetic transports such as
+        // quarkus-amazon-lambda-rest's virtual Netty channel, where writes and
+        // close are synchronous in-memory, leaving the route-handler span unfinished
+        // and orphaning all jakarta-rs.request / aws.http child spans in the trace.
+        // RoutingContext#addEndHandler fires on routing-context completion regardless
+        // of underlying connection state and on both success and failure.
+        routingContext.addEndHandler(ar -> finishHandlerSpan(routingContext));
         DECORATE.afterStart(span);
         span.setResourceName(DECORATE.className(actual.getClass()));
       }
@@ -60,6 +70,19 @@ public void handle(final RoutingContext routingContext) {
     }
   }
 
+  // Idempotently finish the route-handler span. Both EndHandlerWrapper (the
+  // response.endHandler path) and the routingContext.addEndHandler fallback may call
+  // this; the first one to win clears HANDLER_SPAN_CONTEXT_KEY so the second is a no-op.
+  static void finishHandlerSpan(final RoutingContext routingContext) {
+    final AgentSpan span = routingContext.get(HANDLER_SPAN_CONTEXT_KEY);
+    if (span == null) {
+      return;
+    }
+    routingContext.put(HANDLER_SPAN_CONTEXT_KEY, null);
+    DECORATE.onResponse(span, routingContext.response());
+    span.finish();
+  }
+
   private void setRoute(RoutingContext routingContext) {
     final AgentSpan parentSpan = routingContext.get(PARENT_SPAN_CONTEXT_KEY);
     if (parentSpan == null) {