diff --git a/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/main/java/datadog/trace/instrumentation/jms/JMSDecorator.java b/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/main/java/datadog/trace/instrumentation/jms/JMSDecorator.java
index 87fbfc55fc7..22648692810 100644
--- a/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/main/java/datadog/trace/instrumentation/jms/JMSDecorator.java
+++ b/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/main/java/datadog/trace/instrumentation/jms/JMSDecorator.java
@@ -249,6 +249,30 @@ private static boolean isKnownKafkaConnectSuffix(String name, int start, int len
         || (len == 3 && name.regionMatches(true, start, "map", 0, 3));
   }
 
+  /**
+   * Strips URI prefixes ({@code queue://} and {@code topic://}) that IBM MQ's JMS implementation
+   * can return from {@code Queue.getQueueName()} when destinations are created with URI syntax.
+   */
+  static String sanitizeUriPrefix(String name) {
+    if (name == null || name.length() < 9) {
+      return name;
+    }
+    int offset = -1;
+    if (name.length() >= 8 && name.regionMatches(true, 0, "queue://", 0, 8)) {
+      offset = 8;
+    } else if (name.length() >= 8 && name.regionMatches(true, 0, "topic://", 0, 8)) {
+      offset = 8;
+    }
+    if (offset < 0) {
+      return name;
+    }
+    // Strip any remaining leading '/' characters (handles queue:///QUEUE -> /QUEUE -> QUEUE)
+    while (offset < name.length() && name.charAt(offset) == '/') {
+      offset++;
+    }
+    return offset < name.length() ? name.substring(offset) : name;
+  }
+
   public CharSequence toResourceName(String destinationName, boolean isQueue) {
     if (null == destinationName) {
       return isQueue ? queueTempResourceName : topicTempResourceName;
@@ -284,6 +308,10 @@ public String getDestinationName(Destination destination) {
     } catch (Exception e) {
       log.debug("Unable to get jms destination name", e);
     }
+    if (null != name) {
+      // Strip URI prefixes (queue:// and topic://) from IBM MQ destination names
+      name = sanitizeUriPrefix(name);
+    }
     if (null != name && !name.startsWith(TIBCO_TMP_PREFIX)) {
       // Sanitize Kafka Connect schema-derived suffixes from queue/topic names
       return sanitizeDestinationName(name);
diff --git a/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/test/groovy/JMSDecoratorTest.groovy b/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/test/groovy/JMSDecoratorTest.groovy
index 1c8f2dc0bdd..61e76b51fa2 100644
--- a/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/test/groovy/JMSDecoratorTest.groovy
+++ b/dd-java-agent/instrumentation/jms/javax-jms-1.1/src/test/groovy/JMSDecoratorTest.groovy
@@ -83,6 +83,59 @@ class JMSDecoratorTest extends Specification {
     result == null
   }
 
+  def "test getDestinationName strips URI prefixes from IBM MQ destination names"() {
+    given:
+    def decorator = JMSDecorator.CONSUMER_DECORATE
+
+    when:
+    def queue = Mock(Queue) {
+      getQueueName() >> rawQueueName
+    }
+    def result = decorator.getDestinationName(queue)
+
+    then:
+    result == expectedName
+
+    where:
+    rawQueueName                        | expectedName
+    // Triple slash (no queue manager) - most common IBM MQ URI form
+    "queue:///MY.QUEUE"                 | "MY.QUEUE"
+    // Double slash
+    "queue://MY.QUEUE"                  | "MY.QUEUE"
+    // Topic URI prefixes
+    "topic:///MY.TOPIC"                 | "MY.TOPIC"
+    "topic://MY.TOPIC"                  | "MY.TOPIC"
+    // Case insensitive
+    "QUEUE:///MY.QUEUE"                 | "MY.QUEUE"
+    "Queue:///MY.QUEUE"                 | "MY.QUEUE"
+    "TOPIC:///MY.TOPIC"                 | "MY.TOPIC"
+    // Names without prefix pass through unchanged
+    "MY.QUEUE"                          | "MY.QUEUE"
+    "simple"                            | "simple"
+    // Combined: URI prefix + Kafka Connect suffix both stripped
+    "queue:///myqueue_messagebody_0"    | "myqueue"
+  }
+
+  def "test getDestinationName strips URI prefixes from topic destinations"() {
+    given:
+    def decorator = JMSDecorator.CONSUMER_DECORATE
+
+    when:
+    def topic = Mock(Topic) {
+      getTopicName() >> rawTopicName
+    }
+    def result = decorator.getDestinationName(topic)
+
+    then:
+    result == expectedName
+
+    where:
+    rawTopicName                        | expectedName
+    "topic:///MY.TOPIC"                 | "MY.TOPIC"
+    "topic://MY.TOPIC"                  | "MY.TOPIC"
+    "queue:///MY.TOPIC"                 | "MY.TOPIC"
+  }
+
   def "test getDestinationName returns null for TIBCO temp prefix"() {
     given:
     def decorator = JMSDecorator.CONSUMER_DECORATE